YhdA, a thermostable NADPH:FMN oxidoreductase from Bacillus subtilis, reduces quinones via a ping-pong bi-bi mechanism with a pronounced preference for NADPH. The enzyme occurs as a stable tetramer in solution. The two extended dimer surfaces are packed against each other by a 90 rotation of one dimer with respect to the other. This assembly is stabilized by the formation of four salt bridges b...

Growth in children with chronic renal failure caused by polyuric, salt-wasting diseases may be hampered if ongoing sodium and water losses are not corrected. Twenty-four children were treated with polyuric chronic renal insufficiency (CRI; creatinine clearance <65 ml/min per 1.73 m(2)) with low-caloric-density, high-volume, sodium-supplemented feedings. Subsequent growth was compared with that ...

In this study, we proposed the sacrificial anode cathodic protection method as a countermeasure to reduce corrosion of steel sculptures under outdoor conditions and proved anticorrosive effect experimentally. To affix Mg plate specimen, an adhesive bonding strength test was conducted with three types conductive adhesives. Hence, suitability epoxy confirmed, C-clamp experiment supplement connect...

The suggestion that transient states of primary adrenal hypofunction confined to salt conservation can occur in infancy has been most convincingly supported by Jaudon (1946, 1948). Many of his cases, however, showed varying combinations of hyperpigmentation, hypoglycaemia and acidosis, with some having diminished, and others increased, steroid excretion. On the other hand, in recent reports of ...

introduction: caustic ingestion is responsible for a spectrum of upper gastrointestinal tract injury from self-limited to perforation. this study conducted to evaluate clinical characteristics as well as surgical outcomes in patients with caustic ingestion.   materials and methods: between nov1993 to march 2011, 14 adults with a clinical evidence of corrosive ingestion were admitted into our in...

background: vitamin d (vit d) is linked to various conditions including musculoskeletal, metabolic and   cardiopulmonary diseases. however, it is not clear whether correction of vit d deficiency exerts any beneficial effect in patients with pulmonary hypertension. methods: this study was a prospective uncontrolled longitudinal study. patients with pulmonary hypertension and vit d deficiency wer...

adrenal insufficiency is a life-threatening disorder which must be treated with glucocorticoid replacement and needs permanent dose adjustment during patient's different somatic situations. insufficient glucocorticoid doses result in adrenal crisis and must be treated with intravenous hydrocortisone. the patient was known with adrenal insufficiency and was treated optimally with fludrocortisone...