Endothelin-1 (ET-1) has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B (UVB)-induced pigmentation due to its accentuated secretion after UVB irradiation and its function as a mitogen and as a melanogen for human melanocytes. We have recently found that endothelin-converting enzyme (ECE)-1alpha plays a constitutive...

Hepatitis B Virus (HBV) is a causative agent of the most frequent viral infections of man. Since the non-human host range of HBV is restricted to a few animals, such as, chimpanzee, the development of new therapeutics for HBV has been hampered. Several cell lines were developed to identify potential therapeutics against HBV infection. One of these, the HepG2 2.2.15 cell line, was derived throug...

A vérfű-hangyaboglárka, Maculinea teleius (Bergsträsser, 1779) szórványosan fordul elő a Bükki Nemzeti Park Igazgatóság működési területén. Ezen belül Mátra térségében mindössze két, egymáshoz közeli élőhelyfoltban maradt fenn faj, Sirok határában. két területen végeztünk jelölés-visszafogásos vizsgálatot, illetve felmértük petézésre alkalmas őszi vérfű, Sanguisorba officinalis L. virágzatok sz...

tis, which affects nearly 350 million people worldwide. Moreover, HBV plays a critical role in the development of chronic hepatitis and hepatocellular carcinoma. Since the non-human host range of HBV is restricted to a few animals, such as the chimpanzee, the development of new therapeutics for HBV has been hampered. A HepG2-derived HBV producing cell line was developed to identify potential th...

A new algorithm for the management of stable coronary artery disease incorporating CT coronary angiography and fractional flow reserve: how we can improve outcomes and reduce costs 666 Victor Kalff, Stephen J Duffy, Andrew J Taylor 667 William J van Gaal, Kevin Allman 668 Peter Karamoskos 668 Nathan Better, Myles B Webb, David L Prior, Steven A Unger, George Larcos 669 Richard W Harper, Brian S...

Dean, J. G., Brit. med. Y., 1949, 1, 842. ' Market Research Africa (Pty.) Ltd. study on birthplace and overseas travel of the White South African population, Johannesburg (1963) and subsequent studies. ' Allison, R. S., and Millar, J. H. D., Ulster med. Y., 1954, 23, Suppl. No. 2. 'McAlpine, D., Lumsden, C. E., and Acheson, E. D., Multiple Sclerosis: A Reappraisal. 1965. Edinburgh. Hargreaves, ...

The immunologists of my generation were brought up on Sir Macfarlane Burnet's clonal selection theory.' Anticipating Margaret Thatcher's view of society, we believed that all that matters in the immune system is the sum of the decisions taken by individual lympho-cytes. Engagement of its receptor by antigen suffices to drive a lymphocyte to respond. For T cells the only exception is the thymus,...