Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.

The comprehensive relationship of backscattering coefficient (σ 0 ) values from two current X-band SAR sensors (COSMO-SkyMed and TerraSAR-X) with canopy biophysical variables were investigated using the SAR images acquired at VV polarization and shallow incidence angles. The difference and consistency of the two sensors were also examined. The chrono-sequential change of σ 0 in rice paddies dur...

Scattering from man-made objects in SAR imagery exhibits aspect and frequency dependencies which are not well modeled by standard SAR imaging techniques. If ignored, these deviations will reduce recognition performance due to the model mismatch, but when appropriately accounted for, these deviations from the ideal point scattering model can be exploited as attributes to better distinguish scatt...

The use of stereoscopic SAR images offers an alternative to interferometric SAR for the generation of digital elevation models (DEMs). The stereo radargrammetric method is robust and can generate DEMs of sufficient accuracy to geocode SAR images. Previous work has shown that ground coordinates with accuracy of four times the resolution cell can be obtained from ERS data without using any ground...

Recent multigene phylogenetic analyses have contributed much to our understanding of eukaryotic phylogeny. However, the phylogenetic positions of various lineages within the eukaryotes have remained unresolved or in conflict between different phylogenetic studies. These phylogenetic ambiguities might have resulted from mixtures or integration from various factors including limited taxon samplin...

Small molecule chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure activity relationship (SAR), selectivity, cell activity phamacokinetics.

A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure a...

1. GIS Database Development for Disaster Mitigation. This work was a part of a project for the development of disaster mitigation master plan around Mt. Mayon funded by JICA The data used are Aerial Photographs, SPOT, LANDSAT, JERS-SAR, ERS, RADARSAT. Landuse map was created based on these RS data. Riverbeds change cause by very active mud-flow has been mapped. Potential amount of sediment prod...

Saliency map generation in synthetic aperture radar (SAR) imagery has become a promising research area, since it has a close relationship with quick potential target identification, rescue services, etc. Due to the multiplicative speckle noise and complex backscattering in SAR imagery, producing satisfying results is still challenging. This paper proposes a new saliency map generation approach ...

At the early stage of drug discovery, many thousands of chemical compounds can be synthesized and tested (assayed) for potency (activity) with High Throughput Screening (HTS). With ever increasing numbers of compounds to be tested (now often in the neighborhood of 500,000) it remains a challenge to find strategies via sequential design that reduce costs while locating classes of active compound...