One of the innovations in ICD-11 section "schizophrenia and other primary psychotic disorders" is implementation 6 additional domains, which should improve diagnosis treatment these conditions. Cariprazine a new atypical antipsychotic with predominant affinity for D3 receptors, registered Russia schizophrenia, mania, mixed depressive episodes bipolar I disorder. In modern algorithms schizophren...

Introduction Severe mental illnesses such as schizophrenia, bipolar disorder and depressive are common worldwide often have a chronic course. Due to psychiatric ( for example : substance use disorders ) somatic obesity, cardiovascular disease, diabetes comorbidities, mortality is higher in these patients than the general population.Viral diseases are, addition metabolic alterations, among most ...

Background Diagnostic biomarkers of major depressive disorder, bipolar disorder, and schizophrenia are urgently needed, because none are currently available. Methods We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with major depressive disorder (n=9), bipolar disorder (n=6), schizophrenia (n=17), and matched healthy controls (n=19) (cohort 1) using l...

  Since the first report in 1977, many studies have been carried out to determine the efficacy of beta- blockers such as propranolol for the treatment of violent  and aggressive behaviour. Propranolol has also  been used in the treatment of dementia, attending- deficit disorder, schizophrenia, personality disorders, Korsakoff,s psychosis, posttraumatic stress disorder, profound mental retardat...

Background: Psychotic disorder due to industrial drug, such as methamphetamine addiction, is one of the important causes for referral to psychiatric hospital. Psychotic symptoms in these patients are varied. A group of researchers believe that methamphetamine-induced psychosis is completely similar to schizophrenia. Others believe that at least some cases of permanent psychotic clinical manifes...

CONTEXT Traditionally, the search for genes involved in predisposition to major psychoses has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin data suggest that, in addition to genes with specificity for these phenotypes, there exist genes that simultaneously influence susceptibility to schizophrenia, bipolar disorder, and schizoaffective disorder. OBJECTIV...

BACKGROUND Both genetic and environmental factors have been reasoned for cancer development in schizophrenia patients. However, the influence of age of onset and duration of schizophrenia on cancer incidence has rarely been emphasized. Besides, bipolar disorder tends to resemble schizophrenia from the perspective of multiple rare mutations. Comparing pattern and risk of cancers between schizoph...

People with schizophrenia show deficits in processing visual stimuli but neural abnormalities underlying the deficits are unclear and it is unknown whether such functional brain abnormalities are present in other severe mental disorders or in individuals who carry genetic liability for schizophrenia. To better characterize brain responses underlying visual search deficits and test their specifi...

This study aimed to assess the boundaries of the schizophrenia spectrum and whether inclusion of such phenotypes increases power for linkage analysis of schizophrenia. Participants were 234 first degree relatives (FDRs) of 94 schizophrenia probands in Northern Taiwan who completed a direct interview using the Diagnostic Interview for Genetic Studies (DIGS). Based on best estimate diagnosis, the...

psychotic disorders and bipolar disorder (8) and between bipolar disorder and major depressive disorder (9). Although family and twin studies can estimate the shared heritability across disorders, they cannot identify the genetic loci contributing to this overlap. To date, evidence implicating specifi c chromosomal regions and genes in the shared liability to psychotic and mood disorders has la...