We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects. To test this, we established rabbit models of 30 mm sciatic nerve defects, and treated them using either an autograft or a chemically decellularized allogeneic nerve graft w...

BACKGROUND Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal muscle compared with axonal regeneration in a transected sciatic nerve throu...

BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. O...

The sacral plexus forms the sciatic nerve, which leaves the pelvis through the greater sciatic foramen. The anatomic boundaries of the greater sciatic foramen and the relation of the sacral plexus and sciatic nerve to the structures within are identified and described on axial computed tomography (CT). The piriform muscle, which passes through the center of the greater sciatic foramen, is a rec...

Sciatic nerve is the largest nerve in the body originating from the sacral plexus and it supplies the lower limb through its branches. It leaves the pelvic cavity and enters the gluteal region usually through the greater sciatic foramen below the piriformis. It divides into its terminal branches at various levels which determine the length of sciatic nerve. The present study is undertaken to me...

To investigate the clinical efficacy of acupuncture treatment for lumbar spinal canal stenosis and herniated lumbar disc and to clarify the mechanisms in an animal experiment that evaluated acupuncture on sciatic nerve blood flow. In the clinical trial, patients with lumbar spinal canal stenosis or herniated lumbar disc were divided into three treatment groups; (i) Ex-B2 (at the disordered leve...

The innervation area of nociceptive C-fibers in the saphenous nerve of adult rats was detected by the Evans blue technique, in which antidromic excitation of the nociceptive C-fibers causes a visible extravasation of dye in the skin it supplied. One month after cutting the sciatic nerve, the nociceptive C-fibers of the intact saphenous nerve had sprouted to the sciatic area. When capsaicin was ...

Sciatic nerve palsy is a recognised complication of primary total hip replacement. In our unit this complication was rare with an incidence of < 0.2% in the past ten years. We describe six cases of sciatic nerve palsy occurring in 355 consecutive primary total hip replacements (incidence 1.69%). Each of these palsies was caused by post-operative haematoma in the region of the sciatic nerve. Cas...

Damage to the Proximal Sciatic Nerve by Lesions in the Vicinity of the Piriformis Muscle. Lesions of the proximal sciatic nerve in the area of the sciatic notch may occur from endometriosis, tumors, hematomas, fibrosis, aneurysms, false aneurysms, or arteriovenous malformations. Some authors have diagnosed such patients as having PS. Since the piriformis muscle plays no role in these situations...

We have developed a simple and effective animal model to study the distraction neurogenesis utilizing the sciatic nerve-lengthening technique in rats. The model allows macroscopic, physiological, and histological evaluation of the distraction site. Fourteen adult Harlan Sprague Dawley rats (300-350 g) were used in this study. A 10 mm segment of the right sciatic nerve of each animal in the nerv...