BACKGROUND No controlled studies have investigated whether balneotherapy is effective in atopic dermatitis (AD). OBJECTIVES To investigate the efficacy and safety of balneotherapy performed at Comano spa (Trentino, Italy) compared to topical corticosteroids (TCS) in the treatment of AD. METHODS This was an open, randomized, clinical trial including 104 children (aged 1-14 years) with mild t...

Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients atopic dermatitis (AD). However, it is unclear if TARC level can be used as a biomarker to monitor AD improvement in dupilumab treatment, monoclonal antibody targeting IL-4 receptor alpha downregulating IL-13 activity. This was prospective study single tertiary institution investig...

UNLABELLED Few studies concerning the importance of food allergy in adolescents and adult patients with atopic eczema exist. The atopy patch tests with food have mostly been studied in infants and children since food allergy plays a role especially in this age group. AIM The evaluation of the contribution of atopy patch tests in the diagnostic work-up of food allergy (to wheat, cow milk, pean...

Atopic dermatitis (AD) is a chronic relapsing, pruritic, inflammatory skin disease, which results from a complex interplay between genetic and environmental factors. Defensins are broadly dispersed family of antimicrobial peptides which are classified into 2 distinct families: the alpha-defensins and the beta-defensins. The primary function of defensins is to protect the skin from invasion by f...

Atopic dermatitis is a multifactorial skin disease. Epidermal barrier dysfunction, bacterial colonisation, psychological stress, but also type I allergens may aggravate this chronic remittent skin disease. Food allergens may play a role as aggravating factors in a subgroup of patients with atopic dermatitis, however the elicitating allergen profile differs between children and adults. In childr...

Background and aims of the study: Atopic dermatitis is a chronic inflammatory skin disorder that frequently involves some ophthalmic features. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is associated with the generation of cell-mediated immune responses. Although serum MIF levels may be elevated in severe atopic dermatitis, the quantity of MIF in regional oc...

Methods Seventy seven infants with atopic dermatitis were enrolled, who visited pediatric allergy clinic of Busan St. Mary’s Medical Center from January 2005 to January 2012. Infants with serum protein level was lower than normal range for age were classified to Group A (n=27) and normalto Group B (n=50). Age, sex, family history of allergy, and SCORAD score were studied. We examined platelet c...

Methods The patients with AD admitted to outpatient clinic of pediatric allergy department from 1 January 2010 to 30 June 2010 were enrolled to the study. The disease severity and risk factors of the patients were assesed according to the SCORAD index. Skin prick test (SPT) for common food and inhalent allergens were performed to all patients with atopic dermatitis. The food specific IgE blood ...

IMPORTANCE Sleep disturbance is common in children with atopic dermatitis (AD), but effective clinical management for this problem is lacking. Reduced levels of nocturnal melatonin were found to be associated with sleep disturbance and increased disease severity in children with AD. Melatonin also has sleep-inducing and anti-inflammatory properties and therefore might be useful for the manageme...

OBJECTIVE There is a growing body of clinical and laboratory evidence to support the notion that food allergy plays a role in the pathogenesis of atopic dermatitis (AD). However, the incidence of IgE-mediated food allergy in children with AD is not well established. DESIGN A prospective study to determine the prevalence of IgE-mediated food hypersensitivity among patients referred to a univer...