the prevalence of primary infection with t. gondii in pregnant women and risk of congenital infection in their neonates in various parts of tehran are unknown. the prevalence rate of antibodies to t. gondii ranges from 24% in tehran to 62.7% in babol. this study describes the epidemiology of toxoplasma infection in pregnant women in tehran and risk factors of congenital toxoplasmosis in newborn...

BACKGROUND Postmenopausal hormone therapy cessation is associated with a decrease in mammographic density (MD), but it is unknown whether this effect is modified by woman-level characteristics. We investigated whether we could identify characteristics of women who were most likely to experience a decrease in MD due to hormone therapy cessation. METHODS Postmenopausal hormone therapy users wit...

OBJECTIVE Our aim was to compare the effect of central obesity (measured by waist-to-height ratio, WHtR) and total obesity (measured by body mass index, BMI) on life expectancy expressed as years of life lost (YLL), using data on British adults. METHODS A Cox proportional hazards model was applied to data from the prospective Health and Lifestyle Survey (HALS) and the cross sectional Health S...

BACKGROUND The aim of the present cross-sectional study was to use objective methods to assess the association between maternal smoking and body composition in offspring. METHODS A total of 2508 grade 4 school children were enrolled; all underwent lifestyle disease and passive smoking screening. Children were classified into four groups according to their urinary cotinine level and maternal s...

This case-control study compared sociodemographic variables, lifestyle and certain anthropometric parameters of 50 patients hospitalized with colorectal cancer with those of 50 age- and sex-matched controls at a referral hospital in Riyadh. Among cases, females were generally more affected by gastrointestinal symptoms and 4% of male patients had a family history of colorectal cancer. Unlike wei...

c he 1990s ushered in approval of several novel immuosuppressant drugs, including mycophenolate mofetil, acrolimus, cyclosporine microemulsion, everolimus and irolimus, with consequent improvement in clinical utcomes. Subsequently, the transplant community has een challenged with the development and introducion of generic immunosuppression drugs. These drugs epresent a narrow therapeutic index ...

Turbo similarity searching uses information about the nearest neighbours in a conventional chemical similarity search to increase the effectiveness of virtual screening, with a data fusion approach being used to combine the nearest-neighbour information. A previous paper suggested that the approach was highly effective in operation; this paper further tests the approach using a range of differe...

The application of pharmacogenetics holds great promise for individualized therapy. However, it has little clinical reality at present, despite many claims. The main problem is that the evidence base supporting genetic testing before therapy is weak. The pharmacology of the drugs subject to inherited variability in metabolism is often complex. Few have simple or single pathways of elimination. ...

BACKGROUND Screening for obstructive sleep apnea (OSA) is recommended as part of the preoperative assessment of obese patients scheduled for bariatric surgery. The objective of this study was to compare the sensitivity of oximetry alone versus portable polygraphy in the preoperative screening for OSA. METHODS Polygraphy (type III portable monitor) and oximetry data recorded as part of the pre...