YES of the dye or enzyme to the sites of damaged DNA) 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 TESTS of sperm DNA integrity have been used increasingly in the evaluation of the infertile man. These tests have been developed to further our understanding of spermatogenesis and sperm function, and to...

It is my pleasure to write the foreword to this focused edition on sperm DNA fragmentation. This topic is one of the most exciting in male fertility diagnosis and treatment today and it has still so much untapped potential. After years of struggling with outdated diagnostic tools we have discovered DNA fragmentation; a sensitive and specific property of sperm. It is disappointing that there has...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. World Health Organization (WHO) defines infertility as the inability of a sexually active, non-contraceptive couple to achieve pregnancy in 1 year (1). Overall, the worldwide incidence is about 15 % and a male factor is responsible in 20–50% of cases (2). Medical history, physical examination and semen analysis remain...

BACKGROUND Sperm DNA fragmentation (SDF) testing has been recognized as a valuable tool in the evaluation of infertile men. Despite that, its routine use in clinical practice is still hampered by the lack of understanding of the specific clinical scenarios where SDF testing is most beneficial. The aim of this study was to investigate fertility specialists evaluation of infertility of SDF testin...

STUDY QUESTION By investigating a birth cohort with a high ongoing participation rate to derive an unbiased population, what are the parameters and influences upon testicular function for a population not selected with regard to fertility? SUMMARY ANSWER While varicocele, cryptorchidism and obesity may impact on human testicular function, most common drug exposures and the presence of epididy...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Male factor subfertility is present in more than 50% of the couples treated with assisted reproductive techniques. Routine semen analysis provides information on semen volume as well as sperm concentration, motility, and morphology. Standardized methods have been published by the World Health Organization (WHO) (1). N...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Veeramachaneni (1) in response to the practice recommendations by Agarwal et al. (2) reminded the importance of interacting multiple factors on reproductive system. Indeed, it is of paramount importance to rule out reversible factors (such as genital tract infection and exposure to environmental toxicants) during ...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. The authors (Drs. Borini, Tarozzi and Nadalini), in their invited commentary (1) in response to the practice recommendations by Agarwal et al. (2), raised several valid arguments about sperm DNA fragmentation (SDF) testing. In our response to Borini et al., we intend to share additional information on SDF for the read...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. Oehninger’s elegant editorial dwelled on several unresolved i s sues in the context of sperm DNA fragmentation (SDF) (1). Indeed, we appreciate and agree with his comments that development of better diagnostic methodology, evaluation of true functional consequences and understanding of oocyte repair capacity are i...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. The illustrative review and evidence-based guidelines of sperm DNA fragmentation (SDF) testing set forth by contemporary opinion leaders in the field provide readers with a valuable tool for evaluating SDF utility in the modern-day reproductive health practice (1). DNA within spermatozoa normally reside in a dense for...