The structure and dynamics of Opa proteins, which we report herein, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningitidis by human cells and can offer deep understanding into the molecular recognition of pathogen-host receptor interactions. Such interactions are vital to understanding bacterial pathogenesis as well as the mechanism of foreign bod...

Endometrial osseous metaplasia (EOM) is a rare condition characterised by the presence of bone in the uterine cavity. Some patients with this condition present with secondary infertility due to the presence of a foreign body in the endometrium. We report a case of a 39-year-old woman who presented with secondary infertility due to EOM. EOM is a rare cause of infertility that can be easily manag...

INTRODUCTION The Fe-rich olivine end-member, fayalite (Fa100), occurs in the matrix, chondrules, CAIs, silicate aggregates, and dark inclusions in the oxidized Kaba and Mokoia CV3 chondrites, where it is associated with magnetite and troilite. To help constrain the origin of the fayalite, we measured O-isotope compositions of fayalite (Fa98-100) from two petrographic settings of the Kaba meteor...

OBJECTIVES To compare, in a retrospective clinicopathological study, the presentation features of patients with dementia and cortical Lewy bodies (Lewy body dementia) with those of patients with Alzheimer's disease. METHODS From a population of 426 cases from the dementia brain bank, 39 cases of Lewy body dementia and 61 cases of Alzheimer's disease with presentation details were identified. ...

Several vaccinia virus early proteins (encoded by genes B1R, H5R and I3L) synthesized in the presence of an inhibitor of DNA synthesis localize, at least in part, to punctate inclusions that are visible by immunofluorescence in the cytoplasm of poxvirus-infected cells. It is shown that these inclusions contain DNA (visualized by DAPI staining of the infected cells) and that the number of inclus...

Increasing population and Industrialization are key pollutant contributors in water bodies. These wastes are highly hazardous for humansand ecosystem and require a comprehensive, effective treatment before discharge into water bodies. Over the years, many up gradations have been introduced in traditional water treatment methods which were expensive and ineffective especially for removal of heav...

Synovial osteochondromatosis (SO) can occur idiopathic or secondary to osteoarthritis. SO can be easily diagnosed with plain film radiography and clinical findings. In case of disabling osteoarthritis, total knee arthroplasty and removal of all corpora libra are indicated. We present a 71-year-old woman with significant osteoarthritis and severe SO intra-articular and in the suprapatellar bursa...

The coiled body is a specific intranuclear structure of unknown function that is enriched in splicing small nuclear ribonucleoproteins (snRNPs). Because adenoviruses make use of the host cell-splicing machinery and subvert the normal subnuclear organization, we initially decided to investigate the effect of adenovirus infection on the coiled body. The results indicate that adenovirus infection ...

Over the years, there has been an obvious pollution problem in Lagos area, Nigeria with high population of over eleven million and the near absence of waste management infrastructures. Concentrations of some pollution parameters and trace elements (temperature, pH, salinity, SO42-, NO3-, PO43-, F-, DO, BOD, COD and coliform, Cr, Co, Ni, Ag, Cd and Pb) were determined from water bodies of Isolo ...

Environmental and occupational exposure to trichloroethene (TCE) is associated with autoimmune diseases (ADs). However, the mechanisms of TCE-mediated ADs are not fully elucidated. Previous investigations showed that chronic low dose exposure of autoimmune-prone female MRL+/+ mice to TCE resulted in development of autoimmune hepatitis-like disease (AIHLD). To elucidate the mechanisms involved i...