there is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only l-type ca2+ current. in addition, acute ethanol exposure reduces voltage-dependent calcium currents. in the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on l-type ca2+ current. in a na+-k+ free soluti...

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Bosonisation of the massive Thirring model, with a non-minimal and non-abelian gauging is studied in 2+1-dimensions. The static abelian model is solved completely in the large fermion mass limit and the spectrum is obtained. The non-abelian model is solved for a restricted class of gauge fields. In both cases explicit expressions for bosonic currents corresponding to the fermion currents are gi...

RATIONALE IMS 7f-GEO isotope ratio applications increasingly involve analyses (e.g., S- or O- isotopes, coupled with primary ion currents <30 pA) for which quasi-simultaneous arrival (QSA) could compromise precision and accuracy of data. QSA and associated correction have been widely investigated for the CAMECA NanoSIMS instruments, but not for the IMS series. METHODS Sulfur and oxygen isotop...

Sugar transporters in prokaryotes and eukaryotes belong to a large family of membrane proteins containing 12 transmembrane alpha-helices. They are divided into two classes: one facilitative (uniporters) and the other concentrative (cotransporters or symporters). The concentrative transporters are energised by either H+ or Na+ gradients, which are generated and maintained by ion pumps. The facil...

Expression of voltage-gated K channel, shaker-related subfamily, member 5 (KCNA5) underlies the human atrial ultra-rapid delayed rectifier K current (I(Kur)). The KCNA5 polymorphism resulting in P532L in the C terminus generates I(Kur) that is indistinguishable from wild type at baseline but strikingly resistant to drug block. In the present study, truncating the C terminus of KCNA5 generated a...

TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and proposed to be involved in cell depolarization. n excitable cells, TRPM4 may regulate calcium influx by causing the depolarization that drives the activation of voltage-dependent calcium hannels. We here report that insulin-secreting cells of the rat pancreatic -cell line INS-1 natively express TRPM4 proteins...

In this paper, the possible realization of the electromagnetic (EM) absorber as a thin metasurface is considered. The metasurface is based on establishing a passive surface of electric and magnetic currents using the Huygen’s principle. So, the absorber is named Huygens Absorber (HA). The metasurface can be designed using split meander lines with spiral rings. In this way, both sides of the sub...

Gravity currents are very common in nature and may appear in rivers, lakes, oceans, and the atmosphere. They are produced by the buoyant forces interacting between fluids of different densities and may introduce sediments and pollutants into water bodies. In this study, the hydrodynamics and propagation of gravity currents are investigated using WISE (Width Integrated Stratified Environments), ...