Background: The aim of this study was to evaluate whether secreted frizzled-related protein 4 (sFRP4), 5 (sFRP5), and chemerin serum concentrations in early pregnancy are associated with the development gestational diabetes mellitus (GDM) an obese cohort. In previous studies, increased sFRP4 chemerin, decreased sFRP5 were GDM normal overweight women. Methods: exploratory case control study, sFR...

Every year lots of black tea (Camellia sinensis (L.) Kuntze) residue will produce in the factories. These residue are unusable whereas the bio active compounds can be extracted and used in the drag and food industries. Due to mentioned problems, this project was conducted years 2011 - 2012 with the aim to make a study on consecutive isolation of all bio active compounds from tea residu...

Using specific radioimmunoassays, 8 day cultures of Hep G2 cells were shown to contain in their supernatants 16, 74, and 828 ng/mL and in their cell lysates, 8, 55, and 48 ng/2 X 10(8) cells of factor VII, protein C, and protein S, respectively. These proteins and the protein C inhibitor were functionally active, and each of these activities was neutralized by their respective polyclonal antibo...

fully mature dendritic cells (dcs) play pivotal role in inducing immune responses and converting naïve t lymphocytes into functional th1 cells. we aimed to evaluate listeria monocytogenes-derived protein fractions to induce dc maturation and stimulating t helper (th)1 immune responses. in the present study, we fractionated listeria monocytogenes-derived proteins by adding of ammonium sulfate in...

Given the aggressive spread of COVID-19-related deaths, there is an urgent public health need to support development vaccine candidates rapidly improve available control measures against SARS-CoV-2. To meet this need, we are leveraging our existing platform target Here, generated cellular heat shock chaperone protein, glycoprotein 96 (gp96), deliver SARS-CoV-2 protein S (spike) immune system an...

abstract         background and objective: hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis. the aim of this study was to evaluate the effect of inserting protein a signal peptide sequence of pezz18 plasmid on expression and secretion of the recombinant hirudin in e.coli.  ...

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells act as soluble mediators in immunity. Recently, it became clear peroxiredoxins secreted via the exosome-release route, yet remains unclear how this exactly happens why. This review will first introduce briefly possible states of protein cysteines role enzymes their regulation. We then ...

BACKGROUND sAPPα released after α secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function have been described and are present in sAPPβ released at the first step of amyloid peptide cleavage, raising the possibility that sAPPβ could a...

Infectious Pancreatic Necrosis Virus (IPNV) is a member of the family Birnaviridae that has been linked to high mortalities in salmonids. Bacterial based systems as live vectors for the delivery of heterologous antigens offer a number of advantages as vaccination strategies. VP2 is a structural viral protein of IPNV with immunogenicity effects. In this study IPNV was isolated from diseased fry ...

Successful CAR T cell therapy for the treatment of solid tumors requires exemplary expansion, persistence and fitness, ability to target tumor antigens safely. Here we address this constellation critical attributes successful cellular by using integrated technologies that simplify development derisk clinical translation. We have developed a CAR-CD19 secretes CD19-anti-Her2 bridging protein. Thi...