Embryonic implantation is a key step in the establishment of pregnancy. In present work, we have carried out an in-depth proteomic analysis secretome (extracellular vesicles and soluble proteins) two bovine blastocysts embryonic trophectoderm primary cultures (BBT), confirming different epithelial–mesenchymal transition stages these cells. BBT-secretomes contain early pregnancy-related proteins...

The genus Rickettsia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) is comprised of obligate intracellular parasites, with virulent species of interest both as causes of emerging infectious diseases and for their potential deployment as bioterrorism agents. Currently, there are no effective commercially available vaccines, with treatment limited primarily to tetracycline antibiotics, alth...

The Fungal Secretome KnowledgeBase (FunSecKB) provides a resource of secreted fungal proteins, i.e. secretomes, identified from all available fungal protein data in the NCBI RefSeq database. The secreted proteins were identified using a well evaluated computational protocol which includes SignalP, WolfPsort and Phobius for signal peptide or subcellular location prediction, TMHMM for identifying...

Molecular subtype (MS) is one of the most used classifications breast cancer (BC). Four MSs are widely accepted according to receptor expression estrogen, progesterone, and HER2. The impact adipose tissue on BC MS metabolic impairment still unclear. present work aims elucidate alterations in cell lines representing different subjected adipocyte associated factors. Preadipocytes isolated from hu...

Following the advances in human genome sequencing, attention has shifted in part toward the elucidation of the encoded biological functions. Since proteins are the driving forces behind very many biological activities, large-scale examinations of their expression variations, their functional roles and regulation have moved to the central stage. A significant fraction of the human proteome consi...

Introduction: UV light is the principal cause of photoaging, a kind aging. The problem arises because it less enjoyable. Utilizing secretome adipose stem cells (ASC), which rich in growth factors, could be novel anti-photoaging therapy. ASCs has been extensively examined for their role wound healing, but function photoaging just lately investigated. This study looked at changes epidermal and de...

Cartilage is an avascular, alymphatic, and aneurysmal structure, so it difficult to heal properly if injury occurs. Using Chondrogenic Adipose Mesenchymal Stem Cell (AdMSC) secretome as adjuvant one of the therapeutic options overcome problem cartilage. Storage distribution problems must be solved we use this method. This study aims characterize Freeze-dried chondrogenic AdMSC secretome. Secret...

Background . Glioblastoma multiforme (GBM) develops in the hypoxic microenvironment, which plays an important role pathogenesis of disease and is closely associated with tumor growth, development poor prognosis. Hypoxia increases resistance cells (TC) to radiation therapy chemotherapy, promotes appearance aggressive TC phenotype, leading recurrence. The molecular mechanism action on secretome G...