Methanol extracts of Solanum trilobatum Linn Leaf were investigated for anti-inflammatory activity with acute and chronic models. In the doses of 100, 200 and 300 mg kgexhibited significant (P < 0.05) anti-inflammatory activity in all the models tested. The methanol extracts of Solanum trilobatum Linn at 300 mg kg showed maximum inhibition of 54.44 % in carrageenan-induced rat paw oedema while ...

Solanum section Lasiocarpa includes about a dozen species with a center of diversity in theNewWorld tropics. Solanum lasiocarpum and S. repandum (sometimes considered to be conspeciŽc as S. ferox) have an Old World distribution in Asia and the PaciŽc Islands. Several species in this section produce edible fruits, and two, the lulo or naranjilla (S. quitoense) and the cocona (S. sessiliorum) ar...

Older people are frequent users of drugs with sedative properties. However, older people are susceptible to adverse drug events. Sedative drug use has been associated with impaired physical and cognitive function, an increased risk of falls and increased mortality. Sedative load refers to cumulative exposure to multiple drugs with sedative properties. This thesis aimed to investigate sedative l...

A mixture of eight fatty acids (linoleic, oleic, palmitic, stearic, myristic, elaidic, lauric, and palmitoleic acids) at similar concentrations that have been identified in human amniotic fluid exerts anxiolytic-like effects similar to diazepam in adult Wistar rats through actions at γ-aminobutyric acid-A (GABAA) receptors, but unknown is whether any of these fatty acids exerts a predominant ac...

PURPOSE Characterization of sedative, possible anticonvulsant, and protective effects of Acacetin-7-O-glucoside (7-ACAG). METHODS 7-ACAG was separated and its purity was analyzed. Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice. Synaptic responses were acquired from area CA1 of hippocampal slices obtained from male Wistar rats. Rats were subjected t...

Three new Brazilian species of the Brevantherum clade of Solanum (Solanaceae) are described, all closely related to the poorly known Solanum inornatum Witasek. Solanum bradei Giacomin & Stehmann, sp. nov., and Solanum kriegeri Giacomin & Stehmann, sp. nov., differ from S. inornatum in having very small deltate calyx lobes that are not accrescent in fruit. Solanum bradei is a shrub up to 1.8 m w...

Two new species of Solanum section Crinitum are described here. Solanum falciforme Farruggia, sp. nov., closely resembles Solanum crinitum and Solanum lycocarpum, but differs by the presence of falcate trichomes on the young growth. It is endemic to the cerrado and adjacent woodlands of Distrito Federal, Bahia, Goiás and Minas Gerais, Brazil. The other species, Solanum pseudosycophanta Farruggi...

Objectives: Evaluation of antihyperglycemic activity of aqueous extract of leaves of Solanum nigrum (AELSN) in Alloxan induced diabetic rats. Comparison of antihyperglycemic activity of aqueous extract of leaves of Solanum nigrum with standard drug Glimepiride. Methodology: 200-250 g of Wistar rats of either sex were divided into 4 groups (n=6). Group l is normal control (received 0.5ml normal ...

Background Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, anti- inflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. Method Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours be...

acid (GABA) acting on its type A receptor in the mammalian brain explains the pharmacological and therapeutic actions of benzodiazepines which bind to a specific site in the GABAA receptor. However, the usefulness of benzodiazepines as anxiolytics, sedatives, anticonvulsants and muscle relaxants is compromised by the occurrence of several adverse effects such as ataxia, amnesia, alcohol intoler...