In the present study, we examined the gastroprotective effect of selenium against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 80% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of seleniu...

PURPOSE The chemopreventive effects of selenium have been extensively examined, but its role in cancer development or as a chemotherapeutic agent has only recently been explored. Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC develo...

selenium, a trace mineral complement is used as cofactor of antioxidant enzymes that protects fishes against environmental stress agents and enhances performance in fishes. in this study the different levels of organic and inorganic source of  selenium were included in juvenile rainbow trout diet to evaluate feed conversion ratio (fcr), specific growth rate (sgr), weight gain percent (wg), cond...

BACKGROUND Toxic element exposure and essential trace element consumption may have changed after the Chinese economy transformed to a market-oriented system.The objectives of this study were to measure urinary concentrations of toxic (arsenic,cadmium, lead) and essential trace (selenium, zinc, copper) elements among rural residents in Hainan, China and to examine if variations in economic devel...

UNLABELLED Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result devastating consequences. The principle mechanisms underlying neurological damage in HIE resulting from hypoxemia and/or ischemia is deprivation of glucose and oxygen supply which energy failure. A consequent reperfusion injury often deteriorates the brain metabolism by...

In the marine environment, mercury is accompanied by selenium in all investigated species of mammals, birds, and fish--possibly due to a normal homeostatic regulation. It therefore seems likely that selenium will exert its protective action against mercury toxicity in the marine environment, decreasing its detrimental effects on reproduction, behavior, growth, etc. of the organisms and thus pro...

The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementatio...

The present study was designed to investigate the effect of selenium supplementation on dimethylbenz[a]anthracene-induced mammary tumorigenesis in female Sprague-Dawley rats fed either a 5 or 25% corn oil diet, denoted as low fat (LF) or high fat (HF), respectively. Selenium supplementation of LF and HF diets were begun at 21 days of age. In Experiment 1, rats (50 days of age) were given 5 mg o...

INTRODUCTION There are limited reports about selenium status in major thalassemia patients. The aim of this study is evaluation of selenium status in patients with major thalassemia south east of Iran with large sample size and wide range of age. This study compared selenium status with other sites of the world. METHODS In this study 369 cases that had major thalassemia for more than 5 years ...

Arsenic exposure from drinking water is considered to be a risk factor for skin and internal cancers. Animal studies suggest a potential antagonism between arsenic and selenium in the body. We did a case-cohort analysis to prospectively evaluate the association between arsenic-related premalignant skin lesions and prediagnostic blood selenium levels in 303 cases of skin lesions newly diagnosed ...