Lapachol was chemically modified to obtain its thiosemicarbazone and semicarbazone derivatives. These compounds were tested for antimicrobial activity against several bacteria and fungi by the broth microdilution method. The thiosemicarbazone and semicarbazone derivatives of lapachol exhibited antimicrobial activity against the bacteria Enterococcus faecalis and Staphylococcus aureus with minim...

Cutaneous leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, and toxicity or reduced effectiveness of available drugs in addition to complex and prolonged treatments, there is an urgent need to develop alternatives for the treatment for CL with different mechanisms of action. In our effort to search for new promising hits...

The mixed ligand complexes of the type [ML1L2]Cl2, where M=Mn(II), Fe(III),Co(II), Ni(II), Cu(II)L1=pyruvic acid semicarbazone (PYSC) L2= acetone semicarbazone (ACSC). These complexes have been synthesized by the reactions of metal chlorides with two different semicarbazone in 1:1:1 molar ratios. The resulting products have been characterized on the basis of elemental analysis, magnetic measure...

The pharmacokinetics, mass balance, tissue distribution, and metabolism of Co 102862 was investigated in rats after a single oral dose. [(14)C]Co 102862 showed multiexponential pharmacokinetics in rat plasma with an extensive distribution phase. After p.o. administration (approximately 10 mg/kg), the half-lives were long for total radioactivity compared with unchanged Co 102862. Profiles of rat...

The title compound, C13H19N3OS, is a new thia-zolidin-4-one derivative prepared and isolated as the pure (3aS,6R)-diastereisomer from (R)-thio-semicarbazone pulegone. It crystallized with two independent mol-ecules (A and B) in the asymmetric unit. The compound is composed of a hexhydro-indazole ring system (viz. a five-membered di-hydro-pyrazole ring fused to a cyclo-hexyl ring) with a thia-zo...

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, Jawaharlal Nehru Marg, New Delhi 110002, India E mail: schandra_00eyahoo.com Department of Chemistry, Mewar University, NH-76 Gangrar Chhittogarh (Raj), India E mail: [email protected] ABSTACT: A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with 2,6 Diacetyl pyridine bis...

or as a keto group. Of all the approaches to such a synthesis afforded by general methods of organic chemistry, the addition reactions of a double bond, in this case at either C9--Cn or at Cii-Ci2, are the most attractive. The fact that procedures for synthesizing both of these unsaturated compounds from desoxycholic acid have been published (l-3) provides sources of starting material. However,...

In the course of experiments on the enzymatic transformation of steroids we were confronted with the problem of determining quantitatively small amounts of progesterone and pregnenolone (A6-pregnene-3@-ol-20-one). While progesterone can be easily estimated by its absorption maximum at 240 rnp, no spectrophotometric method has been known thus far for the determination of steroids with a ketone g...

An environmentally benign and clean synthesis of aryl-hydrazones by reacting variety of carbonyl compounds with thiosemicarbazide, semicarbazide, aminoguanidine, and phenyl hydrazine has been achieved using aqueous extract of Acacia concinna pods as a natural surfactant type catalyst. We found that the aqueous extract of Acacia concinna pods could be effectively used for the synthesis of aryl-h...