Ztbt20 is a POK family transcription factor and primarily functions through its conserved C2H2 Krüppel type zinc finger and BTB/POZ domains. The present study was designed to define the function of the Zbtb20, in vivo, during mouse spermatogenesis. Immunohistochemical studies revealed that ZBTB20 protein was localized specifically in the nuclei of Sertoli cells in seminiferous tubules. To inves...

An attempt is made to induce the pethidine suppressed gonadal activities by the administration of exogenous gonadotropins (hCG, PMSG, hCG + PMSG). Administration of 5 IU gonadotropins either separately or in combination to the rats treated with pethidine for 30 days resulted in the significant increase in the weight of testis, diameter of testis and seminiferous tubules. Gonadotropin(s) treatme...

In rats with a DHT deficiency induced by finasteride, morphological changes in the seminiferous epithelium were observed. The structural alterations were manifested by the premature germ cells sloughing into the lumen of seminiferous tubules. The etiology of this disorder could be connected with intercellular junctions disintegration. We showed in the immunohistochemical study the changes in ex...

Background: Vasectomy is a simple and highly effective contraceptive method with a low morbidity rate and an extremely low mortality rate. during the past decade millions of men have undergone vasectomy, but there have been surprisingly few studies of morphological effects of genital organs after vasectomy. The most important issues about vasectomy are degenerative changes in testicular tissue,...

The testes produce the male gametes and the male sexual hormones (androgens). The term spermatogenesis describes and includes all the processes involved in the production of gametes, whereas steroidogenesis refers to the enzymatic reactions leading to the production of male steroid hormones. Spermatogenesis and steroidogenesis take place in two compartments morphologically and functionally dist...

In this study, we investigated the expression of TR4 in different stages of seminiferous tubules and the relationship between TR4 and androgen in rat testis. We found that TR4 was stage-dependently expressed in rat seminiferous tubules, T withdrawal induced by high doses of testosterone undecanoate and ethane dimethane sulfonate inhibit TR4 expression in rat testis, and testosterone induced TR4...

to differentiation of the spermatozoon to the mature motile condition. During differentiation, striking variations occur not only in cell shape but also in the ionic composition of the developing spermatozoa and their surrounding media, specifically in the ratio of sodium to potassium (Cragle, Salisbury & Muntz, 1958). The membrane potential (Em) of cells isolated from mouse testis is dependent...

The effect of the carbamate insecticide "carbofuran" on testes of male albino mice and the possible protective role of vitamin C against the insecticide toxicity was assessed. Treating mice with carbofuran for 8 weeks induced a significant decrease in the diameters and germinal epithelial heights of the seminiferous tubules. The histological evidence showed inhibition of spermatogenesis. There ...

The present study was designed to investigate the potential protective effect of Coenzyme Q10 against the testicular toxicity of cadmium in male rabbits. Four groups of animals were used in this study (control, Coenzyme Q10, cadmium chloride-treated (5 mg/kg), cadmium chloride plus Coenzyme Q10 (10 mg/kg) for 30 days). Results showed normal testicular tissue in control and coenzyme Q10 groups. ...

PURPOSE To determine the effect of folic acid (FA) on experimental testicular ischemia/reperfusion (I/R) in rats. METHODS Sixty male Wistar rats were randomly divided into 6 groups. The control group received physiologic saline orally. The sham-operated group received physiologic saline orally then exposed to midline laparotomy without clamping the IR. The I/R rats received oral gavage of the...