hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. the present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on ph-sensitive polymers such as poly (acrylic acid). poly (acrylic acid), p(aa), hydrogel has been synthesized by radical po...

BACKGROUND Approximately 20% of patients undergoing ankle brachial index testing for critical limb ischemia have noncompressible vessels because of tibial artery calcification. This represents a clinical challenge in determining tibial artery patency. We sought to identify the prevalence of tibial artery and pedal arch patency by angiography in these patients. METHODS AND RESULTS One hundred ...

Patient selection is important for targeted therapies, yet phase I/II trials are often underpowered for developing predictors of drug response. The goal of this research was to define genomic predictors for dasatinib that could be prospectively tested in early-phase clinical trials. Gene expression profiles of dasatinib-sensitive and dasatinib-resistant cell lines (n = 23) were compared to deve...

background: children are the most sensitive and vulnerable group in terms of tooth decay. any change or improvement in health-related knowledge and behavior in this group can have long-term and significant impacts on the health of the future generation. thus, the present study was conducted with the aim to determine the relationship of knowledge of oral health-related issues with the decayed, m...

A simple plane wave, ray-tracing approach was used to derive approximate equations for the dielectric microsphere whispering gallery mode WGM resonant wavenumber and quality factor, as dependent on the surrounding medium’s refractive index. These equations are then used to determine the feasibility of a micro-optical sensor for species concentration. Results indicate that the WGMs are not sensi...

A multi-class M/M/1 system, with service rate μin for class-i customers, is considered with the risk-sensitive cost criterion n−1 logE exp ∑ i ciXi(T ), where ci > 0, T > 0 are constants, Xi(t) denotes the class-i queue-length at time t assuming the system starts empty. It is shown that, as n → ∞, asymptotic optimality is achieved by the service policy that prioritizes the classes in decreasing...

The sensitivity analysis of atomic force microscope (AFM) based manipulation of gold spherical nanoparticles in air medium has been carried out in previous research works. In the AFM-based manipulations conducted in various biological liquid mediums, the new environmental parameters associated with these biological fluids also affect the dynamics of the manipulation process. Therefore in this r...

Scarcity of water for irrigation is an alarming issue of Pakistan and the problem is being magnified rapidly with the passage of time. Shortage of water is thus, a limiting factor in increasing per unit area wheat (Triticum aestivum L.) yield that is staple food of most of the people. Eventually, the gap between production and consumption is widening day by day and Pakistan is now suffering fro...

The isovolumic index is the ratio of the duration of isovolumic contraction (IVC) and relaxation (IVR) divided by ejection time (ET), and has been proposed as a more sensitive descriptor of ventricular performance than the systolic time index, which ignores the period of isovolumic relaxation. To determine the effects of acute ischemia on these indices, IVC, IVR, and ET were measured in seven o...