Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

Copyright is held by the author/owner(s). IUI’13, March 19–22, 2012, Santa Monica, California, USA. This work was performed while interning at Adobe Research. Abstract Machine learning techniques used for single-channel sound source separation currently offer no mechanism for user-feedback to improve upon poor results and typically require isolated training data to perform separation. To overco...

Double Benioff zones provide opportunities for insight into seismogenesis because the underlying mechanism must explain two layers of deep earthquakes and the separation between them. We characterize layer separation inside subducting plates with a coordinate rotation to calculate the slab-normal distribution of earthquakes. Benchmark tests on well-established examples confirm that layer separa...

The kinetics of liquid-liquid phase separation and polymer crystallization observed in double-quench experiments with blends of poly(ethylene-co-hexene) and poly(ethylene-co-butene) are studied using time-dependent Ginzburg-Landau Model. Numerical simulations demonstrate that our model can successfully reproduce three experimental phenomena: The decrease in number and size of crystallized spher...

the gas separation performance of commercial ceramic titania and hybrid silica (hybsi®) membranes was assessed using the gas permeation and permporometry methods. results indicated that the hybsi® membranes have a hybrid surface containing regions covered by a polymeric matrix and others with inorganic pores. these membranes have high h2 selectivity, which increases significantly with temperatu...

the present paper compares full kinetics mechanisms in numerical modelling of porous radiant burners (prb), with their reduced forms. the two most frequently used mechanisms of methane combustion (gri3.0 and miller) were selected and their effects were examined on temperature, species concentration, burning speed, and pollutant emission. while the findings of numerical simulation of prb show fi...

DEAD-box proteins are ubiquitous in RNA metabolism and use ATP to mediate RNA conformational changes. These proteins have been suggested to use a fundamentally different mechanism from the related DNA and RNA helicases, generating local strand separation while remaining tethered through additional interactions with structured RNAs and RNA-protein (RNP) complexes. Here, we provide a critical tes...

In this paper, we show how a clear separation between control and data processing in reactive applications increases the range of application of the proof tools of the synchronous reactive model and of the reuse mechanism of the object-oriented approach. We present an approach and some tools that allow this separation in the Ptolemy framework.