Sepsis remains a major cause of morbidity and mortality in surgical patients and trauma victims, mainly due to sepsis-induced multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promising new treatment strategies for sepsis have failed to demonstrate efficacy. Although many reasons could account for this discrepancy, the misinterpretation of preclinical data ...

The aim of this retrospective study was to create guidelines for therapy of severe sepsis in surgical intensive care unit (ICU) for unknown causative agent based on antimicrobial susceptibility of causative bacteria. Seventy-four patients with severe sepsis from surgical ICU in 2003.-2005. were included in study. Their clinical and microbiological data were analyzed from the medical records. An...

Neonatal sepsis is one of the most prevalent infections today, claiming lives almost million newborns in developing countries. Our objective to determine bacteria that cause Egyptian hospitals, as well discover their resistance profiles, allowing for selection appropriate drug combinations against multidrug resistant (MDR) bacteria. Nine hundred and eighty-nine blood samples were collected from...

Objective: To find the incidence of neonatal sepsis, microorganisms involved and their antibiotic sensitivityamong neonates admitted with sepsis during study period.Study Design: Prospective observational study.Place Duration Study: The was carried out at intensive care unit (NICU) combinedmilitary Hospital (CMH), Kharian, Pakistan from January 2019 to December 2020.Materials Methods: After get...

Although blood culture is considered the gold standard for detection of neonatal infections bloodstream, its result can take from 48-72 h and has low sensitivity. In this study, we determined usefulness panbacterial polymerase chain reaction (PCR) panviral RT-PCR in serum, as tests early diagnosis sepsis. We studied 195 patients with clinical sepsis, up to age 28 days, hospitalized Neonatal Int...

UNLABELLED The major impact of sepsis-induced multiple organ dysfunction on healthcare system in the European Union was estimated at 90.4 cases per 100000 inhabitants, compared to 58 per 100000 for breast cancer. The association of organ dysfunctions in terms of both the number of dysfunctions and the degree of organ dysfunction is the most powerful predictor of death in sepsis. AIM To find m...

Objective: We determined the incidence of blood culture-related sepsis, causative bacteria, and antibiotics sensitivity among newborn babies with suggestive signs sepsis admitted at Upper East Regional Hospital in Bolgatanga, Ghana.Design: Prospective cross-sectional studySetting: Newborn Care Unit Hospital, BolgatangaParticipants: Neonates to from August 2019 2020 sepsisMain outcome measures: ...

Toll-like receptors (TLRs) mediate inflammation in sepsis, but their role in sepsis-induced respiratory failure is unknown. Hypoxic pulmonary vasoconstriction (HPV) is a unique vasoconstrictor response that diverts blood flow away from poorly ventilated lung regions. HPV is impaired in sepsis and after challenge with the TLR4 agonist lipopolysaccharide (LPS). Unlike TLR4 agonists, which are pre...

INTRODUCTION The clinical syndrome of neonatal sepsis, comprising signs of infection, septic shock and organ dysfunction in infants ≤4 weeks of age, is a frequent sequel to bloodstream infection and mandates urgent antimicrobial therapy. Bacterial characterisation and antimicrobial susceptibility testing is vital for ensuring appropriate therapy, as high rates of antimicrobial resistance (AMR),...