The recently identified mouse obese (ob) gene apparently encodes a secreted protein that may function in the signaling pathway of adipose tissue. Mutations in the mouse ob gene are associated with the early development of gross obesity. A detailed knowledge concerning the RNA expression pattern and precise genomic location of the human homolog, the OB gene, would facilitate examination of the r...

Software transactional memory (STM) has been proposed to simplify the development and to increase the scalability of concurrent programs. One problem of existing STMs is that of having long-running read transactions co-exist with shorter update transactions. This problem is of practical importance and has so far not been addressed by other papers in this domain. We approach this problem by inve...

Pulsed field gel electrophoresis (PFGE) is an important tool in the construction of physical maps of genomic DNA. The colocalization of probe DNA to a large restriction enzyme generated fragment demonstrates the contiguity of the selected markers. At present, the Southern blot and its subsequent hybridization are the only practical means to colocalize probes on a PFGE restriction. This method i...

Characterization of Xp21 distal to Duchenne muscular dystrophy (DMD) in the region containing the genes for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GKD) has been limited due to a paucity of probes. Two probes were localized between DXS28 (C7) and AHC, the yeast artificial chromosome insert YHX39 (DXS727) and the polymorphic phage clone QST59 (DXS319). A genomic clone,...

There has been a flurry of recent work on the design of high performance software and hybrid hardware/software transactional memories (STMs and HyTMs). This paper reexamines the design decisions behind several of these stateof-the-art algorithms, adopting some ideas, rejecting others, all in an attempt to make STMs faster. The results of our evaluation led us to the design of a transactional lo...

MOTIVATION Searches of biological sequence databases are usually focussed on distinguishing significant from random matches. However, the increasing abundance of related sequences on databases present a second challenge: to distinguish the evolutionarily most closely related sequences (often orthologues) from more distantly related homologues. This is particularly important when searching a dat...