From the Department of Dermatology, University of Cincinnati College of Medicine. Reprint requests: Diya F. Mutasim, MD, Professor and Chairman, Department of Dermatology, University of Cincinnati, PO Box 670592, Cincinnati, OH 45267-0592. E-mail: mutasdf@email. uc.edu. Copyright © 2000 by the American Academy of Dermatology, Inc. 0190-9622/2000/$12.00 + 0 16/2/103582 C onnective tissue disease...

BACKGROUND Clinical algorithms for the workup of celiac disease often recommend the use of serologic assays for initial screening, followed by duodenal biopsy for histologic confirmation. However, the majority of duodenal biopsies submitted to pathology for "rule out celiac" are negative. The objective of this study was to determine the underlying causes for this low diagnostic yield. METHODS...

We report here the serologic detection of a cell surface antigen common to cells transformed by the Abelson murine leukemia virus (A-MuLV) and to normal hematopoietic cells from certain strains of mice. Serum from C57BL/6 mice hyperimmunized with syngeneic A-MuLV lymphoma cells was cytotoxic for the immunizing cells; this reaction was used as the serologic test system for recognition of A-MuLV ...

BACKGROUND Lyme disease is the most common vector-borne disease in the United States, and the number of reported cases has more than doubled between 1992 and 2008. Few studies have explicitly examined sex-based differences in the clinical presentation of or serologic response to early Lyme disease. It is unknown whether the sex-based variability observed in other infectious diseases is relevant...

BACKGROUND Although it is known that first degree relatives of celiac patients have an increased risk for celiac disease few studies are available on its incidence. We investigated the incidence of serologic conversion and of new cases of celiac disease among first degree relatives with negative results at a first screening. METHODS From a total of 634 first degree relatives of 186 biopsy-pro...

Helicobacter pylori infection is common in Jamaica. Describing its epidemiology in a population-based study depends largely on serology, but serologic assays have not been validated in this population. To address this issue, we examined the presence of H. pylori infection in 30 sequential adult patients with gastroduodenal symptoms by three biopsy-based methods (rapid urease test, histology, an...

Serologic reactions in leprosy infection have not been studied with as much interest as other aspects of the infection, for various reasons. Inability to cultivate the causative agent in vitro has made preparation of even relatively purc antigens difficult. Positive serologic tes ts are not characterized by an absolute specificity for leprosy, in part because no antigen. specific f~r the lepros...