BACKGROUND Recent reports of new and important roles for serotonin (5-hydroxytryptamine, 5-HT) in the periphery have substantially increased interest in measuring peripheral serotonin. Nearly all circulating serotonin is found within platelets and this pool has been assessed by measuring serotonin in whole blood or in platelet-rich plasma. Measurement of the much smaller but potentially critica...

NeuroGénétique and Stress, INSERM U471, Institut F. Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment Proc. Abstract Full Text PDF.Corticosteroidserotonin interactions in the neurobiological mechanisms of stress-related disorders. Laurence Lanfumey a,b, Raymond Mongeau a,b, Charles.of acute and chronic stress ...

the effect of hypericin on the expression of morphine-induced conditioned place preference (cpp) was investigated and compared with the effect of the synthetic antidepressants. the cpp paradigms took place over six days using an unbiased procedure. the results demonstrate that intra-peritoneal (ip) injection of morphine sulfate (2.5, 5 and 10 mg/kg) significantly induce the cpp in rat. intra-pe...

Serotonin receptors play central roles in neuromodulation and are critical drug targets for psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to greatly enhance our understanding spatiotemporal dynamics function. While other neuromodulatory have been successfully rendered photoswitchable, reversible photocontrol not achieved, representing a major gap GPCR p...

Serotonin, (5 hydroxy-tryptamine), a naturally occurring compound, is pharmacologically active on intravenous injection in man. It consistently increases the pulse rate but has a variable pressor depressor, or biphasic effect on the arterial pressure. The mode of action of serotonin on these functions is not clear. Serotonin consistently and characteristically increases ventilation. However, it...

CONTEXT Depression in bipolar disorder is clinically indistinguishable from that observed in major depressive disorder. As in major depression, selective serotonin reuptake inhibitors targeting brain serotonin transporters are first-line treatments for bipolar depression. Associations of serotonin transporter promoter polymorphisms and bipolarity have been reported; however, research on alterat...

The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence of platelet serotonin affects neutrophil recruitment in inflammatory responses. Tryptophan hydroxylase (Tph)1–deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis compared with wild-type (WT), primarily drive...

OBJECTIVE To investigate the plasma and cerebrospinal fluid (CSF) concentrations of serotonin in patients with post-stroke depression (PSD). METHODS Serotonin was measured in 30 PSD patients and 30 controls on day 15 and day 30 following stroke. RESULT There was a good correlation between the plasma and the CSF serotonin concentrations in both PSD (r = 0.641, P = 0.001) and control patients...

Tryptophan 2,3-dioxygenase (TDO) is expressed in endometrium and catabolizes tryptophan, a precursor in the biosynthesis of serotonin. Tryptophan metabolism is an important mechanism for regulation of serotonin levels. Preimplantation mouse embryos are known to express serotonin receptors, specifically the 5-HT1D and 5-HT7 serotonin receptor subtypes. Here we demonstrate that Hoxa10 regulates e...

The caput epididymis of some mammals contains large quantities of serotonin whose origin, targets, and physiological variations have been poorly studied. We combined morphological and biochemical techniques to begin approaching these aspects of serotonin in the rat caput epididymis. Serotonin immunostaining was detected in mast, epithelial, and neuroendocrine cells. Epithelial cells displayed i...