Antidepressant drugs are widely recommended for the treatment of depressive disorders, and finding the "right dose for the right patient" is an important issue. Whatever antidepressant is prescribed, a proportion of adult patients with major depression fail to respond satisfactorily to adequate first-line treatment. A frequent strategy for patients with insufficient response to an initial antid...

Background: Post-SSRI sexual dysfunction (PSSD) is a set of heterogeneous disorders, that may arise during the administration antidepressant Selective Serotonin Reuptake Inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitor (SNRIs) persist after their discontinuation. PSSD commonly associated with problems marked distress poor quality life. To date, however, no effective treatment ...

Serotonin (5-HT), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. Serotonin (5-HT) in coordination with hypothalamus plays an important role in the CNS control of appetite, eating behavior, and energy balance and body weight. It has a special role in control of carbohydrate...