BACKGROUND The applications of proteomic strategies to ovine medicine remain limited. The definition of serum proteome may be a good tool to identify useful protein biomarkers for recognising sub-clinical conditions and overt disease in sheep. Findings from bovine species are often directly translated for use in ovine medicine. In order to characterize normal protein patterns and improve knowle...

The relationship between the levels of serum acute phase reactant proteins (alpha 1-acid glycoprotein, alpha 1-antitrypsin, haptoglobin) was investigated in patients with glioblastoma multiforme in relation to their prognosis. Alpha 1-acid glycoprotein was higher in the patients who died within one year after admission than in those with a longer survival time. It is suggested that serum alpha ...

Cryptosporidium parvum (C. parvum) infection is one of the main causes diarrhea in calves. The current study assessed role blood biomarkers (acute-phase proteins (APPs), procalcitonin, neopterin, cytokines, and oxidative stress pathogenesis, diagnosis, prognosis calves naturally infected with C. parvum. Fifty-seven calves, aged from 10 to 45 days, were detected positive for allotted into diseas...

The present study reports on the incidence and degree of intravascular haemolysis in 33 patients with Björk-Shiley tilting disc prosthesis and in 34 patients with Lillehei-Kaster pivoting disc valve prosthesis in the mitral position examined 12 to 24 months after the operation. Serum haptoglobin, serum lactate dehydrogenase, serum bilirubin, and haemoglobin estimations were performed. Significa...

Several investigators have suggested that gastrointestinal inflammation has a role in the pathogenesis of ankylosing spondylitis. To test this hypothesis markers of gastrointestinal immunostimulation, as manifested by serum IgA concentrations, were compared with serum markers of inflammation, as manifested by acute phase proteins. Serum samples from 45 unrelated Caucasian patients with ankylosi...

Lung cancer remains the leading cause of cancer-related mortality worldwide. Early detection of lung cancer is problematic due to the lack of a marker with high diagnosis sensitivity and specificity. To determine the differently expressed proteins in the serum of lung cancer and figure out the function of the proteins, two-dimensional electrophoresis (2DE) and matrix-assisted laser desorption/i...

ECENTLY much attention has been focused on the protein binding of hemoglobin. The hemoglobin binding proteins, collectively called haptoglobin, have been thoroughly studied by several workers.’5 Indentification of these substances has helped to clarify the concept of “renal threshold” for hemoglobin excretion.5’6’9 Subsequently, in an investigation of the difference in “renal threshold” of myog...

Based on our previous studies, differential analysis of N-glycan expression bound on serum haptoglobin reveals the quantitative variation on gastric cancer patients. In this prospective case-control study, we explore the clinically relevant glycan markers for gastric cancer diagnosis. Serum samples were collected from patients with gastric cancer (n = 44) and healthy control (n = 44). N-glycans...

Apolipoprotein L-I (apoL-I) is a human high-density lipoprotein (HDL) component able to kill Trypanosoma brucei brucei by forming anion-selective pores in the lysosomal membrane of the parasite. Another HDL component, haptoglobin-related protein (Hpr), has been suggested as an additional toxin required for full trypanolytic activity of normal human serum. We recently reported the case of a huma...

The aim of this study is to determine the changes in serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) levels before after treatment cattle with dermatophytosis. animal material consisted a total 30 cattle, 20 dermatophytosis 10 healthy, different ages genders. Blood was taken from sick animals twice, treatment, once healthy animals, their separated. obtained sera were stored at -2...