The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increa...

MURATA, K. and NAKAZAWA, K. Lipid Changes in Serum Following Drug Shock and Intoxication. Tohoku J. exp. Med., 1971, 104 (3), 225-232 Serum lipid changes were investigated following a drug shock and 16 intoxication cases. Analyses of serum lipid fractions showed that both drug shock and intoxication resulted in a demonstrable decrease of triglyceride and a trend of increase of phospholipid. The...

The present investigation was undertaken to study the benefical effects of Coenzyme Q10 in streptozotocin (STZ)-induced type I diabetic rats. STZ-diabetes produced a significant increase in fasting glucose levels that was associated with decrease in serum insulin levels. STZ also produced hypercholesterolemia, hypertriglyceredemia, increase in lipid peroxidation and decrease in high density lip...

The regulation of lipid synthesis from acetate in cultures of L cells in response to changes in exogenous lipid supply has been studied, and the enzyme acetyl-CoA synthetase has been investigated in reference to its possible role in the regulation of lipid biosynthesis from acetate. When serum lipid was removed from monolayers of L cells, a relatively rapid stimulation of [14C]acetate incorpora...