OBJECTIVES To identify physical activity that is beneficial for the maintenance of bone strength with increasing age by examining the relation between bone mineral density (BMD) and chronic endurance training in men. BMD at the proximal femur, its subregions, and the lumbar spine, and serum testosterone were compared between two groups of long distance runners with more than 20 years of trainin...

BACKGROUND Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied. METHODS Community-dwelling men, 65 years of age or older, with limitations in mobility and a total serum testosterone level of 100 to 350 ng per deciliter (3.5 to...

OBJECTIVES There are technical limitations for the currently available methods of measuring serum total and free testosterone in females. The study objectives were to evaluate the usefulness of serum total testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), and calculated free testosterone (CFT) in the assessment of androgen status in women investigated for suspected h...

OBJECTIVES To develop a rapid convenient-to-implement high performance liquid chromatography-isotope dilution tandem mass spectrometry (LC-IDMS/MS) method for determination of serum testosterone concentration in routine clinical laboratories. METHODS Following extraction by organic solvents, an Agilent 1200 Series HPLC system coupled to an API 5000 mass spectrometer equipped with an atmospher...

PURPOSE We aimed to evaluate the effect of testosterone replacement therapy (TRT) on cognitive function and depression in men with testosterone deficiency syndrome. MATERIALS AND METHODS We carried out a prospective, placebo-controlled trial involving 106 men with total testosterone levels <3.3 ng/mL and symptoms of hypogonadism. Based on whether the patients received TRT (injection with 1,00...

Background: Preeclampsia along with its complications seems to be one of the major causes of maternal morbidity and mortality. Despite numerous studies, the pathology of preeclampsia has not yet been fully elucidated. This study, therefore, determines whether maternal serum levels of androgen and progesterone are higher in patients with preeclampsia than in matched control subjects. Methods: Se...

OBJECTIVE To evaluate the efficacy of continuous positive airway pressure (CPAP) on serum testosterone in men with obstructive sleep apnea (OSA). METHODS Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before June 2014. Information on characteristics of subjects, study design, pre- and post-CPAP treatment of serum total testosterone, free testosterone ...

OBJECTIVES Hypotestosteronemia has been reported in approximately half of type 2 diabetic men in general. This study aims to assess serum total testosterone levels in type 2 diabetics with erectile dysfunction and to correlate the degree of improvement between sildenafil citrate and testosterone levels. METHODS A cross sectional and prospective comparative interventional study was conducted a...

Background: Circulating testosterone remains the main source of androgens, however only 1%-2% circulates as free testosterone (fT), hormone active form. To compare the performance of serum fT and total testosterone (tT) as predictors of prostate cancer (PCa) detection and aggressiveness. Methods: Serum fT (RIA, pg/mL) and tT (LC/MS, ng/dL) were prospectively determined in 3364 consecutive men w...