Mastigophorenes A—D (1—4) are dimeric herbertenetype sesquiterpenoids found only in the liverwort Mastigophora diclados (BRID.) NEES. They have usually been isolated with their precursor herbertenediol (5). Our recent investigation of a liverwort sample collected from Madagascar, however, did not show any trace of mastigophorenes A and B but revealed the presence of 3—5. The remarkable neurotro...

The present investigation focused on the effects of plant and seed diffusates of Parthenium hysterophorus L. on seed germination of Raphanus sativus L. Level of glucose in germinating seeds as an indirect measure of amylase activity was estimated. About 91.66% viable seed of Raphanus sativus were treated in different concentrations of rhizospheric soil diffusates (PD) and germinating seed diffu...

The sesquiterpene lactones lychnopholide and eremantholide C were isolated from Lychnophora trichocarpha Spreng. (Asteraceae), which is a plant species native to the Brazilian Savannah or Cerrado and popularly known as arnica. Sesquiterpene lactones are known to present a variety of biological activities including antitumor activity. The present paper reports on the evaluation of the in vitro a...

The occurrence of sesquiterpenes was investigated with the geosmin-producing cyanobacterium Calothrix PCC 7507. The essential oil obtained by vacuum destillation was studied in more detail by GC-MS methods and superposition with authentic compounds. Geosmin was the dominating compound while the other sesquiterpenes were minor components. Sesquiterpenes that have not been described before in cya...

Medicinal plants play a crucial role in traditional medicine and in the maintenance of human health worldwide. Sesquiterpene lactones represent an interesting group of plant-derived compounds that are currently being tested as lead drugs in cancer clinical trials. Achillea falcata is a medicinal plant indigenous to the Middle Eastern region and belongs to the Asteraceae family, which is known t...

Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (-)-eriodictyol (10) and nepetin (12), as well as t...

Tithonia diversifolia is an invasive weed commonly found in tropical ecosystems. In this work, we investigate the influence of different abiotic environmental factors on the plant's metabolite profile by multivariate statistical analyses of spectral data deduced by UHPLC-DAD-ESI-HRMS and NMR methods. Different plant part samples of T. diversifolia which included leaves, stems, roots, and inflor...

Glandular trichomes are currently known only to store mono- and sesquiterpene compounds in the subcuticular cavity just above the apical cells of trichomes or emit them into the headspace. We demonstrate that basipetal secretions can also occur, by addressing the organization of the biosynthesis and storage of pyrethrins in pyrethrum (Tanacetum cinerariifolium) flowers. Pyrethrum produces a div...

Wild artichoke (Cynara cornigera), a thistle-like perennial belonging to the Asteraceae family, is native to the Mediterranean region, northwestern Africa, and the Canary Islands. While the pleasant, albeit bitter, taste of the leaves and flowers is attributed to the sesquiterpene lactones cynaropicrin and cynarin, a comprehensive phytochemical investigation still needs to be reported. In this ...

ABSTRACT A continuing search for tumor inhibitors from plant sources has yielded over two hundred extracts with reproducible growth-inhibitory activity. Systematic fractionation, guided by assay in cell culture and animal tumor systems, has led to the isolation of the active principles of more than sixty plants. Chemical studies of novel sesquiterpene lactones, diterpenoid quinone methides, ste...