Monkeys that receive chronic low dose (CLD) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration develop deficits in spatial delayed-response task performance. The present study examined the extent to which SIB-1553A [(+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride], a novel neuronal nicotinic acetylcholine receptor (nAChR) agonist with selectivity for beta4 s...

PURPOSE To compare lesional stereotactic radiosurgery to whole brain (WBRT) radiotherapy with simultaneous in-field boost for brain metastases in terms of overall survival. METHODS A retrospective review was performed on two institutional databases of 500 patients diagnosed with brain metastatic disease who received either stereotactic radiosurgery (SRS, n = 381) or whole brain with simultane...

AIMS To report the feasibility of volumetric modulated arc therapy (VMAT) for neoadjuvant radiotherapy in locally advanced rectal cancer in a dose-escalation protocol and simultaneous integrated boost (SIB) approach. Moreover, the VMAT technique was compared with three-dimensional conformal radiotherapy (3D-CRT) and fixed-field intensity modulated radiotherapy (IMRT), in terms of target coverag...

AIM In recent years, the intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and intensity-modulated radiotherapy with conventional fractionation (IMRT-CF) have been involved in the treatment of nasopharyngeal carcinoma (NPC). However, the potential clinical effects and toxicities are still controversial. METHODS Here, 107 patients with biopsy-proven locally advance...

First-principles lattice determinations of the Standard Model expectation for leading order hadronic vacuum polarization contribution to anomalous magnetic moment muon have become sufficiently precise that further improvement requires including strong and electromagnetic isospin-breaking effects. We provide a continuum estimate strong-isospin-breaking contribution, ${a}_{\ensuremath{\mu}}^{\mat...

Preoxygenation can rapidly improve oxygenation and enhance the security of endotracheal intubation, so it is very essential before endotracheal intubation. The conventional preoxygenation method self-inflating bag (SIB) is not very effective in case of emergency. So our study aims to find a more effective method of preoxygenation in a critical situation.We retrospectively analyzed data of 105 p...

analysis, a series of conditions were recreated in order to determine the situations in which aberrant behavior was more or less likely to occur. In the “attention” condition, occurrences of SIB resulted in attention in the form of statements of disapproval or concern (e.g., “Stop that,” “Don’t do that,” “You’ll hurt yourself”) and/or physical contact (e.g., pats on the back). This condition wa...

BACKGROUND In comparison to the conventional whole-prostate dose escalation, an integrated boost to the macroscopic malignant lesion might potentially improve tumor control rates without increasing toxicity. Quality of life after radiotherapy (RT) with vs. without (18)F-choline PET-CT detected simultaneous integrated boost (SIB) was prospectively evaluated in this study. METHODS Whole body im...

conclusions the results of this study indicates that the single item burnout measure has potential as a brief, sensitive screening measure of burnout due to its brevity, ease of administration and sound psychometric properties and needs to be validated further in larger studies and with other professional groups. results sib scores were highly and positively correlated with mbi-ee scores (r = 0...