BACKGROUND AND OBJECTIVES   The present study was conducted to investigate the possible gastroprotective effect of sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, against indomethacin-induced gastric damage in rats. Further, the study was extended to investigate some possible mechanisms underlying this effect. MATERIALS AND METHODS Forty...

the body, inhibition of PDE-5 increases cGMP levels, reduces intracellular calcium (Ca 2+) and induces vasodilation. The drugs possess identical mechanisms of action, but differ essentially in their duration of action and in some aspects of their pharmacokinetic profiles. Recent clinical studies have shown that the three PDE-5 inhibitors are effective and relatively safe, and that they do not i...

The following therapies may be considered medically necessary for the treatment of pulmonary arterial hypertension (PAH/ WHO Group 1):  ambrisentan (LETAIRIS®) oral;  bosentan (TRACLEER®) oral;  epoprostenol sodium (e.g., FLOLAN®) continuous IV infusion;  Iloprost (VENTAVIS®) Inhalation via nebulizer;  macitentan (OPSUMIT®) oral;  riociguat (ADEMPAS®) oral;  sildenafil citrate (e.g., REV...