In this study, fluorescent dye-conjugated magnetic resonance (MR) imaging agents were investigated in T mode. Gadolinium-conjugated silica nanoparticles were successfully synthesized for both MR imaging and fluorescence diagnostics. Polyamine and polycarboxyl functional groups were modified chemically on the surface of the silica nanoparticles for efficient conjugation of gadolinium ions. The d...

We report a facile strategy to synthesize silica nanoparticles-coated graphene oxide (GO-SiO2) nanohybrids in a water-alcohol mixture at room temperature. AFM observations revealed that silica nanoparticles with ca. 50 nm in size were densely and evenly covered on graphene oxide sheets. Due to the space layer of silica nanoparticles, micro-scale GO-SiO2 hybrid plates could be individually dispe...

Hypothesis Silica nanoparticles can be dispersed in organic solvents (organosols) using surfactants, such as didodecyldimethylammonium bromide (DDAB). DDAB analogues prepared with lathanide tetrahalide counterions, either a high-magnetic moment ion (HoCl3Br, DDAH) or low-magnetic moment one (NdCl3Br, DDAN), are expected to produce charged particles but only DDAH-stabilized dispersions are expec...

Mesoporous-silica-coated Gd2O3:Eu/silica nanoparticles were synthesized by a multistep chemical process and characterized by XRD, TEM and N2 adsorption/desorption isotherms in terms of size, morphology and porosity. The core Gd2O3:Eu obtained by this method was highly luminescent upon excitation, giving the function of cell imaging upon incubation with the human cervical carcinoma (HeLa) cells....

Magnetic targeting is useful for intravascular or intracavitary drug delivery, including tumor chemotherapy or intraocular antiangiogenic therapy. For all such in vivo applications, the magnetic drug carrier must be biocompatible and nontoxic. In this work, we investigated the toxic properties of magnetic nanoparticles coated with polyethylenoxide (PEO) triblock copolymers. Such coatings preven...

Aim: We investigated the application of fluorescein (FL)-entrapped magnetosomes, in other words, silica-coated iron oxide nanoparticles entrapped within niosomes (SIO/NIO), magnetically assisted photodynamic therapy (PDT) vitro. Methods: Panc-1 cells were treated with and without external magnetic guidance, irradiated blue light. Results & conclusion: Upon photoactivation, FL-entrapped magn...

background: recently, some new nanobiosensors using different nanoparticles or microarray systems for detection of mycotoxins have been designed . however, rapid, sensitive and early detection of aflatoxicosis would be very helpful to distinguish high-risk persons.objectives: we report a highly sensitive competitive immunoassay using magnetic/silica core shell as a signal intensifier for the de...

Abstract Background Nanoparticles are being increasingly used in biomedical applications owing to their unique physical and chemical properties small size. However, biophysical assessment evaluation of side-effects remain challenging. We addressed this issue by investigating the effects silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate [MNPs@SiO 2 (RITC)] on aspects, su...

A novel and convenient synthetic strategy for the preparation of magnetically responsive silica nanospheres decorated with mixed ligand protected gold nanoparticles is described. Gold nanoparticles are attached to the silica surface via stable amide bond formation. The hierarchical nanospheres show promising results as reusable and efficient catalysts for esterification reactions and they can b...