We investigated the role of K+ channels and intracellular Ca2+ stores in the relaxations induced by the NO donor 3-morpholinosydnonimine (SIN-1) and 8-bromo-cGMP (8-BrcGMP), 8-(4-chlorophenylthio)-cGMP (pCPT-cGMP), and α,β-methylene-ATP in isolated segments of rat ileum. The inhibitory responses to SIN-1 and the cGMP analogs were not influenced by the K+ blockers apamin, charybdotoxin, iberioto...

Background Sinomenine (SIN) has been shown to have protective effects against brain damage following traumatic brain injury (TBI). However, the mechanisms and its role in these effects remain unclear. This study was conducted to investigate the potential mechanisms of the protective effects of SIN. Methods The weight-drop model of TBI in Institute of Cancer Research (ICR) mice were treated wi...

In Schizosaccharomyces pombe, a late mitotic kinase pathway called the septation initiation network (SIN) triggers cytokinesis. Here we show that the SIN is also involved in regulating anaphase spindle elongation and telophase nuclear positioning via inhibition of Klp2, a minus end-directed kinesin-14. Klp2 is known to localize to microtubules (MTs) and have roles in interphase nuclear position...

Previous studies have identified sin mutations that alleviate the requirement for the yeast SWI/SNF chromatin remodelling complex, which include point changes in the yeast genes encoding core histones. Here we characterise the biochemical properties of nucleosomes bearing these mutations. We find that sin mutant nucleosomes have a high inherent thermal mobility. As the SWI/SNF complex can alter...

of the Christian tradition,1 and is stated in its fullest form in the theological doctrine of God's impeccability.2, God is not only free from sin, He is incapable of moral deviation. God not only does not sin, He cannot sin. This is generally held to be part of what is communicated in the claim that God is perfectly good. On the surface, at least, this doctrine appears to be in conflict with t...

Interest has appeared from the people need to borrow main agricultural products. Over the time, it has been the subject for many theories-for interest, and against interest-all of them having various reasons. Church has, in general, forbidden interest, but the economic reasons have won, considering fair to reward the creditor for the time passed from the moment of loaning, for the monetary deva...

This paper describes a course I developed on the Economics of Sin that integrates ethical and economic material.1 My hope is that this paper will be useful to economists interested in exploring ethically complex economic phenomena and to philosophers who are interested in the ethical implications of economic markets and policies. In keeping with this agenda, I proceed by discussing a framework ...

An overview of the observation of CP violation in the neutral B system, and the measurements of the CP-violating asymmetry sin2β with B → charmonium K0 S ,L events, performed by the BABAR and Belle experiments at the SLAC and KEK B factories is given. In addition, the measurements of sin2β with several other modes are described, including B → φK0 S , which, as the leading contribution is from a...

A new study of fission yeast cell division has revealed a coupling between cytoplasmic partitioning and the turning-off of cytokinesis signalling that may be mediated by asymmetric protein distribution.