In intervention studies in which randomization to groups is not possible, researchers typically use quasi-experimental designs. Time series designs are strong quasi-experimental designs but are seldom used, perhaps because of technical and analytic hurdles. Statistical process control (SPC) is an alternative analytic approach to testing hypotheses about intervention effects using data collected...

Measurement based software process improvement is nowadays a mandatory activity. This implies continuous process monitoring in order to predict its behavior, highlight its performance variations and, if necessary, quickly react to them. Process variations are due to common causes or assignable ones. The former are part of the process itself while the latter are due to exceptional events that re...

Although several Cre-loxP-based gene knockout mouse models have been generated for the study of gene function in alveolar epithelia in the lung, their applications are still limited. In this study, we developed a SPC-Cre-ER(T2) mouse model, in which a tamoxifen-inducible Cre recombinase (Cre-ER(T2)) is under the control of the human surfactant protein C (SPC) promoter. The specificity and effic...

Males have a higher morbidity and mortality for neonatal respiratory distress syndrome (RDS) than females, and respond less well to hormone therapy designed to prevent RDS by stimulating fetal pulmonary surfactant production. We have shown that male fetuses exhibit delayed production of pulmonary surfactant. We tested the hypothesis that the sex difference in fetal pulmonary surfactant producti...

To cite: Fretheim A, Tomic O. BMJ Qual Saf 2015;24: 748–752. INTRODUCTION Time series plots are widely used, across sectors and media, probably because many find them easy to understand. Figure 1 is a time series plot of how the readmission rate in a hospital changed over time (constructed data set). Statistical process control (SPC) and interrupted time series (ITS) designs are two closely rel...

This thesis documents the design of logical superposition coded (SPC) modulation for implementation in wireless video multicast systems, to tackle the issues caused by multi-user channel diversity, one of the legacy problems due to the nature of wireless video multicasting. The framework generates a logical SPC modulated signal by mapping successively refinable information bits into a single si...

The single-pill combination (SPC) comprising nebivolol (5 mg), a vasodilatory β1 -selective antagonist/β3 -agonist, and valsartan (80 mg), a renin-angiotensin-aldosterone system inhibitor, is the only Food and Drug Administration-approved β-blocker/renin-angiotensin-aldosterone system inhibitor SPC for hypertension. Additive effects of four nebivolol/valsartan SPC doses (5 mg/80 mg, 5/160 mg, 1...

In manufacturing industries, development of measurement leads to increase the number of monitoring variables and eventually the importance of multivariate control comes to the fore. Statistical process control (SPC) is one of the most widely used as multivariate control chart. Nevertheless, SPC is restricted to apply in processes because its assumption of data as following specific distribution...