The formation of pressure ulcers is dependent on multiple factors including ischemia-reperfusion (IR). This study assessed the mechanism of a previously reported murine model of cutaneous IR injury. Three cycles of IR (days 1-3) by external application of two magnetic plates were performed to induce pressure ulcer formation. Increased infiltration of neutrophils and macrophages, and augmented e...

BACKGROUND The rotation fasciocutaneous flap for buttock pressure sore coverage has the distinct advantage of allowing rerotation in the event of ulcer recurrence. The authors describe their approach of preserving and incorporating musculocutaneous perforators into the conventional rotation design. METHODS The skin incision is the same as that for the conventional gluteal rotation flap. The f...

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a tropical ulcerative skin disease. One of the most intriguing aspects of this disease is the presence of extensive tissue damage in the absence of an acute inflammatory response. We recently purified and characterized a macrolide toxin, mycolactone, from M. ulcerans. Injection of this molecule into guinea pig skin reproduced cell d...

UNLABELLED Background. Vacuum-assisted closure (V.A.C.® Therapy, KCI, San Antonio, TX) has been widely used to increase the healing rate of a variety of wounds. It has been hypothesized that one of the actions of VAC is to increase perfusion and subsequent oxygenation of tissue. The aim of the present study was to investigate the effect of VAC therapy on transcutaneous oximetry measurements (T...

Basal cell carcinoma of the penis is rare. A patient who presented with a penile and scrotal ulcer due to basal cell carcinoma is reported. Wide local excision and split skin grafting were performed to excise the lesion completely.

A 61-year-old Japanese woman developed pressure ulcer on her sacral and coccygeal area due to a long-term bed rest. After she received the treatment by bucladesine sodium ointment, trafermin (recombinant human basic FGF) splay and TIELLE ® (Johnson & Johnson Co) hydropolymer dressing, the ulcer gradually reduced in size and depth. However, the improvement of the fissure-like ulcer decelerated w...

We present the case of a 12-year-old boy with furuncular myiasis living in an area with continental climate. The boy was admitted to our clinic with a wound on his nape, which started as a little acne and progressed to a large wound in which pus flowed continuously. He complained of itching and was treated with penicillin, clarithromycin, terbinafine, and ibuprofen in the last 2 months, with no...

AIMS AND OBJECTIVES The study aimed to evaluate the predictive validity and accuracy of a new pressure ulcer risk assessment scale in two Indonesia intensive care units (ICUs). BACKGROUND Several risk assessment scales have been designed to identify patients at risk of developing pressure ulcers in ICU. However, the relative weight of each variable that contributes to pressure ulcer developme...

This study aims to investigate the sensitization of human skin points along certain meridians related to visceral disease by using the pressure-pain threshold (PPT) as an indicator. We detected and compared the PPTs of people with and without gastric ulcer or gastritis on the related acupoints, abdomen area, and back area with von Frey detector and observed the similarities and differences unde...

This study combines non-invasive hyperspectral imaging with an experimentally validated skin optical model and inverse algorithm to monitor diabetic feet of two representative patients. It aims to observe temporal changes in local epidermal thickness and oxyhemoglobin concentration and to gain insight into the progression of foot ulcer formation and healing. Foot ulceration is a debilitating co...