When a liquid slams into solid, the intermediate gas is squeezed out at speed that diverges when approaching moment of impact. Although there mounting experimental evidence instabilities form on interface during such an event, understanding nature these limited. This study therefore addresses stability liquid-gas with surface tension, subject to diverging flow in phase, where and phase are both...

Src-homology-2-containing inositol-5´-phosphatase, SHIP (also known as SHIP1), is a tumor suppressor that negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway by hydrolyzing the PI3K-generated second messenger phosphatidylinositol-3,4,5-triphosphate (PIP 3) to PI-3,4-P 2. SHIP expression is restricted primarily to hematopoietic cells, but has also been reported in mesenchymal s...

BACKGROUND Th2-dominated inflammatory response in the airway is an integral component in the pathogenesis of allergic asthma. Accumulating evidence supports the notion that the phosphoinositide 3-kinase (PI3K) pathway is involved in the process. We previously reported that SHIP-1, a negative regulator of the PI3K pathway, is essential in maintaining lung immunohomeostasis, potentially through r...

Two signaling molecules have been implicated in the modulation of immune receptor activation by inhibitory coreceptors: an inositol polyphosphate 5'-phosphatase, SHIP, and a tyrosine phosphatase, SHP-1. To address the necessity, interaction, or redundancy of these signaling molecules, we have generated SHP-1- or SHIP-deficient B cell lines and determined their ability to mediate inhibitory sign...

fter 20-30 years ships are at the end of their effective service life [9] and they are then dismantled. Ship dismantling in the US is quite different from in developing countries, and ship deconstruction costs are much higher in the US. The ship deconstructors in developing countries earn significant profits because of lower recycling costs of the ships and higher resale values of the scrap. Pr...

We recently purified and cloned a 145-kDa protein that becomes tyrosine phosphorylated and associated with Shc in response to multiple cytokines. Based on its predicated amino acid sequence and its enzymatic activity, we have called this protein SHIP, for Src homology 2-containing inositol phosphatase. To gain further insight into the intracellular pathways that this putative signal transductio...