Abstract Current systemic therapies for inflammatory gastrointestinal (GI) disorders are unable to locally target lesions and have substantial side effects. Here, a compact mesoscale spring actuator capable of delivering an anchoring drug deposit point locations in the GI tract is demonstrated. The mechanism demonstrated here intended complement existing ingestible capsule‐based sensing communi...

Filaggrin (FLG) is a key cornified envelope and epidermal barrier protein. FLG mutations are the most strongly implicated genetic risk factor for atopic eczema (AE). part of gene complex, called differentiation complex (EDC), genes which contribute to various aspects function. siRNA knockdown in keratinocytes caused global reduction EDC Keratin (KRT) expression concomitant with up-regulation bo...

In normal or nonmalignant cells, TGF-β inhibits cellular proliferation through activation of the SMAD-dependent canonical signaling pathway. Recent findings demonstrate that the protein TMEPAI1 can block the cytostatic effects of the canonical TGF-β signaling pathway, while activating cellular proliferation through the noncanonical, SMAD-independent TGF-β signaling pathway. As TMEPAI1 shows inc...