Transitions between the small cell lung cancer and the non-small cell lung cancer phenotype occur during clinical tumor progression in small cell lung cancer. We have previously developed a culture model which mimics these transitions. In our model, the insertion of the v-Ha-ras oncogene into c-myc overexpressing NCI-H82 small cell lung cancer cells induces features characteristic of non-small ...

AIMS Small cell prostatic cancer is a rare but aggressive disease. Currently, its histogenetic origin is unclear and its distinction from metastatic small cell lung cancer is challenging. The aim of our study was to determine whether the ERG rearrangement commonly observed in acinar prostatic cancer can distinguish small cell prostatic cancer from small cell lung cancer samples. METHODS AND R...

As discussed in the “Non–Small-Cell Lung Cancer” chapter, there are two major subdivisions of lung cancer: small-cell lung cancer (SCLC) and non–small-cell lung cancer (NSCLC). SCLC is decreasing in frequency in the United States, with recent data showing it represents only 14% of lung cancers. This chapter provides information on the staging and prognosis, pathology and pathophysiology, treatm...

To examine whether a monoclonal antibody, TFS-4, can distinguish small-cell lung cancer from non-small-cell lung cancers, an extensive survey of fresh lung tumors, cancers from other organs, and normal tissue specimens has been carried out. The antibody has been shown to react specifically with small-cell lung cancer (15 of 15) but not with squamous cell carcinoma (0 of 20), adenocarcinoma (0 o...

It is estimated that in early stage lung cancer, that PET scan shows unsuspected metastases in about 10% of patients. In a study led by MacManus et al, an evaluation was done for patients with Stage III non-small lung cancer to determine the role of treatment. Small cell lung cancer is a particular type seen under the microscope. Non-small cell refers to essentially all other types of lung canc...

Worldwide, lung cancer is the leading cause of cancer death in men and has surpassed breast cancer as the leading cause of cancer death in women in the latter part of 1980s. It is estimated that more than 500 000 new cases are diagnosed each year; approximately 15–20% of lung cancer patients have small cell lung cancer (SCLC) and the other patients have non-small cell lung cancer (NSCLC), such ...

Lung cancer is one of the most prevalent cancers in both men and women worldwide. The nucleic acid G4 structures have been implicated transcriptional programmes cancer-related genes some such as lung cancer. However, role dominant resolvase DHX36 progression remains unknown. In this study, by bioinformatic analysis public datasets (TCGA GEO), we find an independent prognosis indicator non-small...

Lung cancer is the leading cause of cancer-related death in United States and incidence this never smokers about 15-20% males 50% females. Non-small cell lung carcinoma (NSCLC) constitutes 75% to 80% these cancers more common than small (SCLC) smokers. Treatment NSCLC has been rapidly evolving with discovery targetable mutations like EGFR, ALK. Despite this, prognosis remains guarded given diag...