Small intestinal bacterial overgrowth has been found to be associated with a variety of gastrointestinal disorders such as irritable bowel syndrome, inflammatory disease, and, in recent years, diabetes mellitus and systemic sclerosis, among other extraintestinal diseases. Several novel diagnostic tools for small have emerged several therapeutic approaches proposed. Therefore, it become necessar...

WATANABE, H., HIWATASHI, N. and GOTO, Y. Biopsy under Direct Vision for the Diagnosis of Crohn's Disease. Tohoku J. exp. Med., 1979, 129 (1), 1-8-In order to clarify the role of biopsy in distinguishing Crohn's disease from intestinal tuberculosis before surgery, the histologic findings of the biopsy specimens from 8 cases of Crohn's disease were investigated in comparison with those from 19 ca...

In about 70% of patients Crohn's disease (CD) affects the small intestine. This disease location is stable over time and associated with a genetic background different from isolated colonic disease. A characteristic feature of small intestinal host defense is the presence of Paneth cells at the bottom of the crypts of Lieberkühn. These cells produce different broad spectrum antimicrobial peptid...

We report our experience with small-bowel push enteroscopy in 50 patients. The indications for push enteroscopy were: anaemia/occult gastrointestinal bleeding (22 patients); overt gastrointestinal bleeding (17 patients); abnormal small-bowel radiology (8 patients) and miscellaneous (3 patients). In those with undiagnosed gastrointestinal bleeding/anaemia, abnormalities were detected in 24/39 pa...

Immunoproliferative small intestinal disease (IPSID) is a rare disorder, which can progress to malignancy and invasion. Herein, a male patient is presented with hypoalbuminemic ascites and a history of chronic diarrhea five years before. Small intestinal biopsy and immunohistochemical study suggested the diagnosis of IPSID; the patient was then successfully treated with antibiotics. Considering...

CONTEXT Studies of mortality in celiac disease have not taken small-intestinal pathology into account. OBJECTIVE To examine mortality in celiac disease according to small-intestinal histopathology. DESIGN, SETTING, AND PATIENTS Retrospective cohort study. We collected data from duodenal/jejunal biopsies taken between July 1969 and February 2008 on celiac disease (Marsh stage 3: villous atro...

Segmental dilatation of the intestine in pediatric age group is a rare entity. Patients usually present with partial intestinal obstruction which may delay surgical decision. Our case was an 18-month-old girl, who presented with partial intestinal obstruction, provisionally diagnosed as a case of Hirschsprung's disease. Diagnostic evaluation with contrast study gave a clue of small intestinal o...

Capsule endoscopy is a noninvasive diagnostic method used in various gastrointestinal diseases such as Crohn’s disease and celiac disease. Immunoproliferative small-intestinal disease (IPSID) is a proliferative disorder of IgA-producing B lymphocytes [1]. IPSID has been characterized by the loss of the mucosal circular folds, a thickened, cobblestone appearance of the mucosa, and multiple sessi...

Systemic amyloidosis frequently involves the small intestine. However, its association with diverticular disease has been seldom reported to date. To draw attention to this rare but potentially harmful association, we herein present an additional case of small bowel diverticular disease associated with amyloidosis.

The small intestine has been considered inaccessible for a long term. The development of single-balloon endoscopy has greatly improved the diagnosis and treatment possibilities for small intestinal diseases.In this study, we aimed to explore the demographic characteristics and small intestinal diseases of patients who underwent single-balloon enteroscopy between 2009 and 2014 at our endoscopy c...