Current Opinion in Allergy and Clinical Immunology 2008, 8:103–109 Purpose of review There is recognition that respiratory sensitization is an occupational hazard of high concern. Despite international regulatory requirements there is no established protoco for the efficient prospective identification of chemical respiratory sensitizers. We review the predictive behaviour of available methods a...

The understanding of individual differences in response to threat (e.g., attentional bias) is important to better understand the development of anxiety disorders. Previous studies revealed only a small attentional bias in high-anxious (HA) subjects. One explanation for this finding may be the assumption that all HA-subjects show a constant attentional bias. Current models distinguish HA-subject...

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That hypoxic tissues are more resistant to the effects of radiation than well-oxygenated tissues has been known for many decades, and repeated in vitro demonstrations have confirmed that to achieve the same degree of cytotoxicity, hypoxic cells require about three times the radiation dose that well-oxygenated cells need. Hypoxic cell sensitizers enhance the tissue response to standard radiation...

Insulin resistance is an important "upstream" driver for reproductive and metabolic abnormalities in women with Polycystic Ovary Syndrome (PCOS). This theoretical background is now supported by substantial evidence for treating women with PCOS with insulin sensitising agents such as metformin or the thiazolidinediones. Although the available data are based upon studies comprised of relatively s...

Photodynamic Control-Mediated Holographic Composites In article number 2100363, Jae-Won Ka and co-workers propose new holographic composites with photodynamic control, composed of photosensitizers, singlet oxygen receptors, polymeric binders. Upon laser irradiation, photoexcited sensitizers generate oxygens, which can be detected by their receptors structural changes. Such changes within the co...

Recently, reactive dyes have attracted a lot of attention for dye-sensitized solar cell applications. This study endeavors to design dye sensitizers with enhanced efficiency photovoltaic cells by modifying the blue 5 (RB 5) and brown 10 10) dyes. Three different strategies were used sensitizers, their was compared using density functional theory (DFT). The optimized geometry, bang gap values, s...

Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight coupling of these events poses a dual conundrum: mechanistically, as the FOXO1 corepressor of glucokinase is unknown, and clinically, as inhibition ...