The effect of a long-acting somatostatin analogue SMS 201.995 (SMS; Sandoz) on basal and gastrin-stimulated growth of 4 human colon cancer lines was studied in vitro and in vivo. Proliferation assay was done with overnight [75Se]selenomethionine uptake after 5 days of incubation. Gastrin concentrations used were 5e-10 M and 1e-7 M. SMS concentrations were from 2e-12 M to 2e-7 M. Cell lines LIM ...

The effect of a long-acting somatostatin analogue SMS 201.995 (SMS; Sandoz) on basal and gastrin-stimulated growth of 4 human colon cancer lines was studied in vitro and in vico. Proliferation assay was done with overnight |75Se|selenomethionine uptake after 5 days of incubation. Gastrin concentrations used were 5e-10 M and le-7 M. SMS concentrations were from 2e-12 M to 2e-7 M. Cell lines LIM ...

Some clinical results indicate that somatostatin (sms) might be useful in the treatment of advanced prostate cancer (HRPC). Because of its transient in vivo half-life only more stable derivatives of sms are of interest in this context. Recent studies have shown that natural sms can be conjugated to a carbohydrate (smsdx) with preservation of sms-like effects on the prostatic tumor cell proteome...

Smart Machining Systems (SMS) are an important part of Life Cycle Engineering (LCE) since its capabilities include: producing the first and every product correct; improving the response of the production system to changes in demand (just in time); realizing rapid manufacturing; and, providing data on an as needed basis. Thereby, SMS improve the performance of production systems and reduce produ...

A common refrain in chronic disease management is that patients and clinicians need to enact new roles: patients as their own caregivers; clinicians as professional supporters of patient self-management activities. These roles are central to self-management support (SMS), an approach that emphasizes a clinical partnership, and promotes patient identification and achievement of realistic and sho...

Due to age dependent organ manifestation, diagnosis of Marfan syndrome (MFS) is a challenge, especially in childhood. It is important to identify children at risk of MFS as soon as possible to direct those to appropriate treatment but also to avoid stigmatization due to false diagnosis. We published the Kid-Short Marfan Score (Kid-SMS) in 2012 to stratify the pre-test probability of MFS in chil...

The rehabilitation of U.S. military servicemembers (SMs) who have sustained a traumatic loss of one or both lower limbs requires outcome measures that can assess their physical capabilities in comparison with their uninjured colleagues. Describing reference ranges for the 6-minute walk test (6MWT) in both populations will help clinicians develop appropriate goals for rehabilitation and document...

Snyder-Robinson syndrome (SRS, OMIM: 309583) is an X-linked intellectual disability (XLID) syndrome, characterized by a collection of clinical features including facial asymmetry, marfanoid habitus, hypertonia, osteoporosis and unsteady gait. It is caused by a significant decrease or loss of spermine synthase (SMS) activity. Here, we report a new missense mutation, p.Y328C (c.1084A>G), in SMS i...

PURPOSE: Simultaneous multislice (SMS) imaging is an increasingly popular parallel imaging method for accelerating fMRI, but typically requires array coils with many coils, and therefore much storage space and computation time. Here, we investigate the effects that coil compression can have on functional activation for both SMS and conventional fMRI. Although SMS imaging has been demonstrated u...

Previous work by the authors has argued that SMS is a more appropriate medium for providing egovernment services in developing countries and an SMS-based e-government model has been proposed. The model consists of five levels: Notification, Presentation, Communication, Transaction, and Integration; and provides guidance for governments who want to initially focus on delivering their public serv...