The syndrome of apathy, defined as a reduction in goal-directed behavior (GDB), has profound consequences for morbidity and mortality in the patient and for family-caregiver burden. Apathy is one of the primary neuropsychiatric syndromes associated with the disruption of the frontal-striatal system, but the behavioral and biological mechanisms underlying apathy are not well understood. Apathy i...

OBJECTIVE To identify distinct behavioral phenotypes of behavioral-variant frontotemporal dementia (bvFTD) and to elucidate differences in functional, neuroimaging, and progression to residential care placement. METHODS Eighty-eight patients with bvFTD were included in a cluster analysis applying levels of disinhibition and apathy (Cambridge Behavioural Inventory-Revised) to identify phenotyp...

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In the last few years, a growing number of studies have been devoted to affective disturbances in Alzheimer disease, AD. These studies showed that apathy is a symptom clearly distinct from depression, and that confusion between apathy and depression appears to be one major cause of variability in the assessment of the frequency of depression in AD. We present the results of four studies from ou...

Background: Low testosterone in men with Parkinson’s disease may be associated with non-motor symptoms of the disease, such as apathy. Objective: To determine the association between free serum testosterone level and apathy in elderly men with Parkinson’s disease. Methods: Consecutive non-demented patients (n = 49) and knowledgeable informants (n = 40) participated in the study. Patients and in...

BACKGROUND Low testosterone in men with Parkinson's disease may be associated with non-motor symptoms of the disease, such as apathy. OBJECTIVE To determine the association between free serum testosterone level and apathy in elderly men with Parkinson's disease. METHODS Consecutive non-demented patients (n = 49) and knowledgeable informants (n = 40) participated in the study. Patients and i...

BACKGROUND Apathy is a negative symptom associated with poor psychosocial functioning in schizophrenia but has not been sufficiently studied as predictor of poor functioning in first episode psychosis (FEP). OBJECTIVE The main aim of the current study was to evaluate if apathy predicts poor functioning after 1 year in FEP patients in the context of other clinical variables with influence on o...

This essay turns to ancient sources in order to rethink the relationship between political apathy and democracy. If modern democratic theorists place political apathy entirely outside of democracy – either as a destructive limit upon the full realization of a democratic polity, or, more sanguinely, as a pragmatic necessity which tempers democracy so that it may function in a workable yet watere...