We report a mother and son who each presented in infancy with hypotonia and global developmental delay. Subsequently, in both subjects, mild mental handicap was diagnosed in association with temporal lobe arachnoid cysts. Mendelian inheritance of this phenotype seems likely and macroscopic cerebral dysplasia in general may be underdiagnosed in people with familial, mild mental handicap.

more and more first-class entrants. We must have more teachers, more nurses, more scientists, and so on, and they must all be of the first rank. One is sometimes tempted to wonder whether there really are enough highly intelligent people to go round. We certainly cannot afford to waste any of them, and we ought perhaps to spend rather more time considering them and their needs than we do. They ...

BACKGROUND Although voice tremor is one of the most commonly noted clinical features of essential tremor (ET), there are nearly no published data on the handicap associated with it. METHODS The Voice Handicap Index (VHI) was self-administered by participants enrolled in a research study at Columbia University Medical Center. The VHI quantifies patients' perceptions of handicap due to voice di...