Lung cancer is among the highly prevalent and deadly cancers in the United States and worldwide. Cells that are cancerous exhibit higher rates of glycolysis as compared to normal cells. In an attempt to exploit this uniquely enhanced glucose-dependent ATP generation phenomenon, the authors hypothesize that exposure of cancer cells to normal organic metabolites that are capable of inhibiting gly...

T HE platinized platinum electrode develops a rapidly responding and readily recorded potential in the presence of hydrogen dissolved in blood. A sensitive procedure for detecting and localizing left-to-right shunts in the catheterization laboratory"2 and in the operating room3 has been developed with use of such an electrode on the tip of a cardiac catheter. Hydrogen has been found to be compl...

OBJECTIVES A reduction in bond strength of composite to bleached enamel has been reported immediately after bleaching treatment. Application of some antioxidant agents may decrease the adverse effects of whitening agents on bond strength and enhance composite bond to enamel. This study aimed to assess the effect of green tea, sodium ascorbate, sage and grape seed extract on bond strength of com...

Chelation therapy is thought to not only remove contaminating metals but also to decrease free radical production. EDTA chelation therapy, containing high doses of vitamin C as an antioxidant, is often used in the treatment of diseases such as diabetes and cardiovascular diseases but the effectiveness of this treatment may be variable and its efficacy has not been demonstrated conclusively. The...

This study investigated the effects of a novel antibacterial film based on chitosan, carboxymethyl cellulose, sodium alginate, tea polyphenols, ascorbic acid, and tangelo peel extract postharvest quality reactive oxygen species metabolism fruit during storage. The composite significantly reduced decay rate weight loss, delayed reduction in total soluble solids titratable acidity, retained firmn...

Herein we describe an efficient and rapid access to 3′-deoxy-3′-(4-substituted-1,2,3-triazol-1-yl)-thymidine derivatives using 1,3-dipolar cycloaddition reaction catalyzed by copper(I). Innovative conditions allow us generate target compounds in a one-pot mixing 3′-azido-3′-deoxythymidine, alkyne, copper sulfate pentahydrate, sodium ascorbate tris(benzyltriazolylmethyl)amine water:tert-butanol ...

Ascorbate in an aqueous solution is easily oxidized by molecular oxygen in the presence of cupric ion, thus producing reactive oxygen species and exhibiting cytotoxicity. In order to increase the antitumor activity of ascorbate, we used the innocuous form of cupric ion complexed with glycylglycylhistidine, a tripeptide designed to mimic the specific Cu(ll) transport site of albumin molecule. Al...