In addition to its known effect in suppressing the deacetylation of the nucleosomal core histones, sodium butyrate in the concentration range 0.5 to 15 mM causes a selective inhibition of [32P]phosphate incorporation into histones H1 and H2A of cultured HeLa S3 cells. No commensurate general inhibition of phosphorylation is seen in the non-histone nuclear proteins of butyrate-treated cells, but...

AIM Paracrine interaction between macrophages and adipocytes in obese visceral fat tissues is thought to be a trigger of chronic inflammation. The immunomodulatory effect of the short chain fatty acid, butyric acid, has been demonstrated. We hypothesize that sodium butyrate (butyrate) attenuates inflammatory responses and lipolysis generated by the interaction of macrophages and adipocytes. M...

The expression of ErbB proteins, together with heregulin, was found to be increased in colon cancer cells compared with normal mucosa, and heregulin-stimulated activation of ErbB signaling was observed to contribute to the proliferation of colon cancer cells. Butyrate produced during the fermentation of fiber by intestinal bacteria is known to exert diverse anticancer effects, including the ind...

4.2 RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 4.2.1 1H MR spectroscopy of SW620 cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 4.2.1.1 Assignment of 1D and 2D proton MR spectra . . . . . . . . . . . . . . 98 4.2.2 SW620 cells treated with sodium butyrate . . . . . . . . . . . . . . . . . ....

The effects of varying concentrations of sodium chloride and formaldehyde on the activity of “usual” and “atypical” serum cholinesterases using o-nitrophenyl butyrate as substrate have been examined. The atypical enzyme has been shown to be more sensitive to either inhibitor than the usual enzyme. These results indicate two new methods for differentiating the two variants using a noncholine est...

Short chain fatty acids (SCFAs) are the products of colonic bacterial degradation of unabsorbed starch and non-starch polysaccharide (fibre). They are important anions in the colonic lumen, affecting both colonocyte morphology and function. The three main acids (acetate, propionate, and butyrate) stimulate colonic sodium and fluid absorption and exert proliferative effects on the colonocyte. Ex...