Mitochondria of AS-30D rat ascites hepatoma cells are found to be the main target for Zn(2+) and sodium selenite (Na(2)SeO(3)). High [mu]M concentrations of Zn(2+) or selenite were strongly cytotoxic, killing the AS-30D cells by both apoptotic and necrotic ways. Both Zn(2+) and selenite produced strong changes in intracellular generation of reactive oxygen species (ROS) and the mitochondrial dy...

UNLABELLED Nonthyroidal illness syndrome (NTIS) is marked by low T3 and high reverse T3 levels. The physiopathology is poorly understood but involves oxidative stress-induced disruption of the iodothyronine deiodinases, which activate or inactivate thyroid hormones. Selenium, an essential trace element, exerts antioxidant function mainly through the thioredoxin reductase (TRx) and glutathione p...

The determination of members of the genus Salmonella present in small numbers in egg solids has always been somewhat uncertain. Among other things, the nature of the product tends to reduce the selectivity of the various media used for their detection. Also some of the enrichment media tend to inhibit the growth of certain types of Salmonella (Ayres, 1953; Banwart and Ayres, 1953; Hurlev and Ay...

None of the authors of this manuscript has any financial or personal relationship with other people or organizations that could inappropriately influence their work. Sodium selenite, the source of the selenium, was of high purity. Saccharomyces cerevisiae JS, JN and JW, isolated from brewer’s yeast powder, are used widely in selenium enrichment. Zygosaccharomyces rouxii F, FM and PC, isolated f...

BACKGROUND Microorganisms that are exposed to pollutants in the environment, such as metals/metalloids, have a remarkable ability to fight the metal stress by various mechanisms. These metal-microbe interactions have already found an important role in biotechnological applications. It is only recently that microorganisms have been explored as potential biofactories for synthesis of metal/metall...

Triphala (TP) is composed of Emblica officinalis, Terminalia chebula, and Terminalia belerica. The present study was undertaken to evaluate its anticataract potential in vitro and in vivo in a selenite-induced experimental model of cataract. In vitro enucleated rat lenses were maintained in organ culture containing Dulbecco's Modified Eagles Medium alone or with the addition of 100μM selenite. ...