Since metastatic lesions of solid tumors are the major cause of mortality in cancer patients, understanding the molecular mechanisms of metastasis is of paramount importance. Although extensive knowledge has been accumulated regarding the early steps in metastasis--starting with the departure of cancer cells from their primary sites, to their transit through the hematogenous and/or lymphatic sy...

It is unknown why the speech center is located in the left cerebrum. There are no apparent structural asymmetries in organs related to vocalization including the respiratory system. However, beneath the diaphragm, the solid liver is located right, and the deformable air-containing stomach is located left. During vocalization, abdominal muscles contract, elevate the diaphragm through the displac...

Organ transplantation is indeed a revolution in management of end-stage organ failure. The one year graft survival rates for solid organs now routinely exceed 85 per cent for the kidney, liver and heart. The enhanced success rate is due to better immunosuppression, improvement in surgical techniques, organ preservation and better understanding of the immunology of rejection. The small intestine...

Before the introduction of highly active antiretroviral therapy in the mid-1990s, transplantation centers were understandably reluctant to provide scarce solid organs for patients infected with the human immunodeficiency virus (HIV). However, because treated patients can now expect to live substantially longer than before, many will have end-stage organ disease long before they have life-threat...

2281 include heart transplantations, but its design was revised to focus on those organs for which there is a greater need. It is hoped that funds will become available to add heart transplantation if the preliminary results are positive. Progress in the clinical management of HIV infection has been influenced not only by investigators and clinicians, but also by patients and their advocates. R...

Sensory information is acquired in spatial coordinate systems linked to sense organs, yet movement must be executed in coordinate systems linked to motor effector organs. Neurophysiological experiments are yielding new insights into how the brain transforms coordinate systems to facilitate movement.

Previous dynamic characterizations of the cercal mechanosensory hairs of crickets have generally been limited to the first resonant frequency and associated deflection shape. A more complete description of the mechanical dynamics of these structures could be obtained by an experimental modal analysis. This paper describes a method by which a full experimental modal analysis, giving natural freq...