Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...

Macrophage responses to infection with Mycobacterium tuberculosis (MTB) and treatment with soluble isoniazid (INH) plus rifabutin (RFB) versus microparticles containing equivalent amounts of drugs were compared. It was investigated whether macrophages driven to alternative activation upon infection with MTB could be rescued to display the classical activation phenotype. It was established that ...

To protect the spinal cord from traction myelopathy during surgical correction of deformities, it is proposed to use an extended epidural block. The developed technique was applied in 34 patients. Myelopathy, subsequently arrested with complete restoration function lower extremities, occurred one patient day after termination article presents results studying patterns distribution solutions wat...

Olmesartan medoxomil is a poor water soluble drug. There are numerous approaches available and reported in literature to enhance the solubility of poor water soluble drugs among which cyclodextrin complexation is predominant. β-cyclodextrin was used since this possess a special ability to complex with drugs enabling them to increase solubility, reduce bitterness, enhance stability and decrease ...

Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...

We have demonstrated the toxicity of diazepam and the safety of ketamine hydrochloride following intra-arterial injection in an anaesthetized animal model. The pathogenesis of gangrene following intra-arterial injection of drugs is unclear. Clinical reports and this experiment suggest that it only follows injection of highly membrane-soluble drugs. Early swelling and disruption of capillary end...

Oral drug delivery is considered as the most preferable route for chronic treatment of various diseases, due to its greater stability, flexibility in formulation, dosage accuracy, low cost of manufacturing and packaging and patient friendly administration [1]. But most of the drugs belong to poorly water soluble (BCS Class II) category and suffering from poor dissolution and it is worst if give...

BACKGROUND The Fas/Fas ligand (FasL) system is a major regulator of apoptosis. Chemotherapeutic drugs have been shown to induce Fas expression on the surface of lung cancer cells, and cancer cell apoptosis. However, this mechanism is not considered to be associated with Fas expressed on lung cancer cells. Soluble Fas and FasL concentrations are reportedly elevated in the peripheral blood of pat...

et al. (1948) used 3 per cent ethyl-alcohol for dissolving the insoluble drugs before adding to their synthetic media. With both the above methods the drug does get uniformly distributed in the media but gets ultimately precipitated if it is highly insoluble. The drugs reported in this paper are mostly insoluble in water beyond a dilution of 1 in 10,000 and are soluble in alcohol in a minimum o...

nowadays, many people prefer to use herbal remedies instead of chemical treatments, because of a fewer side effects. it seems that herbal drugs can be useful to neuroinflammation diseases like alzheimer. alzheimer disease (ad) is caused by the oxidative stress and inflammatory compounds such as cytokine and beta-amyloid. it causes learning problems due to damage in cells in the hippocampus area...