been detected in central nervous system of rodents, nonhuman primates and human based on radioligand binding studies. KOR agonists may have pharmacotherapeutic potential in the treatment of pain or hyperalgesia and in the management of psychostimulant addiction. However, the clinical application of selective KOR agonists, such as ethylketocyclazocine and U-50488, has been limited by the occurre...

Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic prolif...