Introducción: Los balones intragástricos (BIG) de llenado líquido han surgido como opción segura y eficaz para el manejo sobrepeso obesidad, en nuestro medio hay poca información acerca su implementación obesidad riesgo bajo moderado. Objetivo: Evaluar la del BIG contenido individuos con moderado términos pérdida peso, seguridad tolerancia a 4, 6 12 meses tratamiento. Materiales métodos: estudi...

Alzheimer's disease (AD) is increasingly considered as a disconnection syndrome. Previous studies of the structural connectome in early AD stages have focused on mild cognitive impaired subjects (MCI), considering them as a homogeneous group. We studied 168 subjects from the Alzheimer's Disease Neuroimaging Initiative database (116 MCI and 52 cognitively normal subjects). Biomarker-based strati...

BACKGROUND Panthothenate kinase-associated neurodegeneration (PKAN) belongs to a group of hereditary neurodegenerative disorders known as neuroacanthocytosis (NA). This genetically heterogeneous group of diseases is characterized by degeneration of neurons in the basal ganglia and by the presence of deformed red blood cells with thorny protrusions, acanthocytes, in the circulation. OBJECTIVE ...

In this issue, Oiso et al. [1] present an unusual case of pigmentary mosaicism. A 29-year-old man with mental deficiency had hypermelanotic macules arranged in a phylloid pattern. Cytogenetic analysis of peripheral blood lymphocytes showed 3 different aberrant cell types containing either a monocentric or a dicentric ring chromosome 13, or monosomy 13. Remarkably, no normal karyotype could be f...

Pantothenate kinase- associated neurodegeneration (PKAN) syndrome is a rare autosomal recessive disorder characterized by progressive extrapyramidal dysfunction and iron accumulation in the brain and axonal spheroids in the central nervous system. It has been shown that the disorder is caused by mutations in PANK2 gene which codes for a mitochondrial enzyme participating in coenzyme A biosynthe...