The sodium/iodide symporter (NIS) has been identified as an attractive target for cancer therapy. The efficacy of 131I-iodide for NIS-expressing tumor therapy may be limited by a combination of poor cellular retention and unfavorable physical characteristics (long physical half-life and low linear-energy-transfer [LET] radiative emissions). On the other hand, 211At-astatide is also transported ...

objective(s): gallium-68 dota-dphe1-tyr3-octreotide (68ga-dotatoc) has been applied by several european centers for the treatment of a variety of human malignancies. nevertheless, definitive dosimetric data are yet unavailable. according to the society of nuclear medicine and molecular imaging, researchers are investigating the safety and efficacy of this radiotracer to meet food and drug admin...

The fate of small doses of isotopically labeled isologous hemoglobin was studied in the rat. When haptoglobin depleted animals were given 2.0 mg of (59)Fe hemoglobin intravenously, nearly half was trapped by the kidneys. Kidney (59)Fe activity disappeared slowly over several weeks. Whatever iron was lost from the kidneys was largely reutilized. In contrast, the porphyrin of hemoglobin absorbed ...

LLE Review, Volume 147 150 Introduction High concentrations of tritium develop on stainless-steel (SS) surfaces exposed to a tritium atmosphere.1 These high concentrations are attributed to tritium dissolution within the adsorbed water layers present on all metal surfaces.1–4 Tritium dissolved within these layers contributes $20% to the total inventory absorbed by SS.1 Additionally, these water...

For a dietary amino acid to be retained in tissue protein in an animal, the amino acid needs to be ingested by the animal and absorbed from the intestinal tract. While the absorption of amino acids is a concept that can easily be defined, it is difficult to measure. Instead, the digestibility of amino acids is measured. Digestibility is defined as the difference between the amount of a certain ...

The intestinal transport of lamivudine, a nucleotide reverse transcriptase inhibitor, was investigated using the single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are ...

A Monte Carlo model of radiative transfer in multi-phase dusty media is applied to the situation of stars and clumpy dust in a sphere or a disk. The distribution of escaping and absorbed photons are shown for various filling factors and densities. Analytical methods of approximating the escaping fraction of radiation, based on the Mega-Grains approach [4], are discussed. Comparison with the Mon...

The addition of adrenaline to solutions of etidocaine or lignocaine for extradural administration resulted in significantly lower plasma koncentrations in both the arterial blood (14% decrease for etidocaine and 43% decrease for lignocaine) and venous blood (35% and 60% decreases for etidocaine and lignocaine respectively). The nett absorption over the first 4 h after administration, measured f...

Objective(s): Gallium-68 DOTA-DPhe1-Tyr3-Octreotide (68Ga-DOTATOC) has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Admin...

In this study, the effect of grain boundary on frictional behavior under oil-lubricated condition was investigated by varying size (crystallite size) pure Fe samples prepared via physical vapor deposition. A high fraction in sample yielded a low friction coefficient μ case lubrication oil that formed chemisorbed film surface material. Thick absorbed layer observed only with boundary. These resu...