there are increasing data on novel tumor markers such as gelatinase a, which play a key role in tissue invasion and metastasis. since prostate cancer is one of the common malignancies, we designed a simple and applicable indi¬rect hemagglutination (iha) test for determination of total gelatinase a in se¬rum samples. in this study, we have analyzed the circulating form of gelatinase a (mmp-2) in...

BACKGROUND It is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of populations and ancient human migration. All these events and variations in the mitochondrial genome are...

PURPOSE There are few data regarding the epidemiology of hereditary or familial prostate cancer (PCa) in East Asians, especially in Korean men. Therefore, we evaluated the incidence of familial and hereditary PCa and the relation between socioeconomic status and the incidence of nonsporadic prostate cancer (NSPC). MATERIALS AND METHODS We collected data from all patients who were treated for ...

Objective(s): The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials ...

Background: According to the EAU guidelines, a life expectancy of more than 10 years is considered an important factor in the treatment of prostate cancer. The Charlson score is used to predict mortality based on comorbidies.The purpose of this study was to investigate the relationship between age, Charlson score and outcome in patients with cT3a prostate cancer. Materials and Methods: Between ...

objective(s): bonenavi, a computer-aided diagnostic system, is used in bone scintigraphy. this system provides the artificial neural network (ann) and bone scan index (bsi) values. ann is associated with the possibility of bone metastasis, while bsi is related to the amount of bone metastasis. the degree of uptake on bone scintigraphy can be affected by the type of bone metastasis. therefore, t...

we report our experience with 124 patients were referred 70 our urology clinic in sina hospital for urinary retention. serum psa analyzed by using a monoclonal assay. all patients underwent digital rectal examination. the patients devided in 3 groups: group 1 (87 men) with a serum psa level less than 4 ng/ml, group 2 (26 men) with a serum psa level 4-10 ng/ml and group 3 (11 men) with a serum p...

68Ga Prostate-specific membrane antigen (PSMA) is an increasingly popular radiopharmaceutical tracer in prostate cancer and is becoming increasingly researched in other cancers such as breast cancer, renal cell carcinoma, glioblastoma multiforme, among others. Cholangiocarcinoma is the second most common primary hepatic malignant tumor; it is an aggressive tumor with a 5-year surviva...